Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL (Q24299061)

3

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Christopher J. Schofield

5

0 references

Peter J. Ratcliffe

Peter J Ratcliffe

8

0 references

David Ian Stuart

David I Stuart

9

0 references

Timothy D W Claridge

4

Timothy D W Claridge

0 references

Christopher J A Pugh

6

Christopher W Pugh

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Yvonne Jones

10

E Yvonne Jones

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Patrick H. Maxwell

7

Patrick H Maxwell

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author name string

Wai-Ching Hon

1

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Michael I Wilson

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

2

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publication date

27 June 2002

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language of work or name

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417

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issue

6892

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page(s)

975-8

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Proteolysis and the cell cycle: with this RING I do thee destroy

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

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Hydrogen bonding and biological specificity analysed by protein engineering

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Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

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Processing of X-ray diffraction data collected in oscillation mode

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