Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease (Q33951094)

30 July 2017

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title

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease (English)

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30 July 2017

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Blum D

1

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30 July 2017

Torch S

2

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30 July 2017

Lambeng N

3

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30 July 2017

Nissou M

4

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30 July 2017

Benabid AL

5

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30 July 2017

Sadoul R

6

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30 July 2017

Verna JM

7

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30 July 2017

1 October 2001

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30 July 2017

Progress in Neurobiology

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30 July 2017

65

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30 July 2017

135-172

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30 July 2017

2

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Frequency of dementia in Parkinson disease.

30 July 2017

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7 January 2021

Pharmacological protection against the cytotoxicity induced by 6-hydroxydopamine and H2O2 in chromaffin cells.

1 reference

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7 January 2021

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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7 January 2021

MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes.

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7 January 2021

The Bcl-2 protein family: arbiters of cell survival

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7 January 2021

Regulation of JNK signaling by GSTp

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7 January 2021

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

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7 January 2021

1-Methyl-4-phenylpyridine (MPP+): regional dopamine neuron uptake, toxicity, and novel rotational behavior following dopamine receptor proliferation

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7 January 2021

Brain Peroxidase and Catalase in Parkinson Disease

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7 January 2021

The determination of hydroxydopamines and other trace amines in the urine of parkinsonian patients and normal controls

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7 January 2021

Plasticity of nerve afferents to nigrostriatal neurons in Parkinson's disease

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7 January 2021

The Bcl-2 protein family

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7 January 2021

Attenuation of 6-hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice.

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7 January 2021

Death receptors: signaling and modulation

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7 January 2021

Apoptosis control by death and decoy receptors

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7 January 2021

Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease

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7 January 2021

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

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7 January 2021

Control of apoptosis by Rel/NF-kappaB transcription factors

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7 January 2021

Apoptosis and its role in human disease

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7 January 2021

The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons.

1 reference

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7 January 2021

Dopamine Neurotoxicity: Inhibition of Mitochondrial Respiration

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7 January 2021

Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice

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7 January 2021

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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7 January 2021

Lesions of Central Norepinephrine Terminals with 6-OH-Dopamine: Biochemistry and Fine Structure

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7 January 2021

p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells.

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7 January 2021

6-hydroxydopamine-induced nuclear factor-kappa B activation in PC12 cells.

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7 January 2021

Extracellular toxicity of 6-hydroxydopamine on PC12 cells.

1 reference

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7 January 2021

Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease.

1 reference

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7 January 2021

Interaction between 6-hydroxydopamine and transferrin: "Let my iron go"

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7 January 2021

Apoptosis without caspases: an inefficient molecular guillotine?

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7 January 2021

Apoptosis: checkpoint at the mitochondrial frontier.

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7 January 2021

Caspases induce cytochrome c release from mitochondria by activating cytosolic factors

1 reference

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7 January 2021

Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis

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7 January 2021

Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine

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7 January 2021

Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid.

1 reference

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7 January 2021

Biochemical pathways of caspase activation during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Programmed cell death: does it play a role in Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Parkinson's disease in twins studied with 18F-dopa and positron emission tomography

1 reference

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7 January 2021

Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: behavioral and biochemical evidence

1 reference

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7 January 2021

Criteria for diagnosing Parkinson's disease

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7 January 2021

Is idiopathic parkinsonism the consequence of an event or a process?

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Effect of 1-methyl-4-phenylpyridinium (MPP+) on mitochondrial membrane potential in cerebellar neurons: interaction with the NMDA receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases.

1 reference

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7 January 2021

The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factor-kappaB in cellular models of Parkinson's disease

1 reference

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7 January 2021

Apaf1 and the apoptotic machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Glucose protection from MPP+-induced apoptosis depends on mitochondrial membrane potential and ATP synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

MPP+ selectively affects calcium homeostasis in mesencephalic cell cultures from embryonal C57/Bl6 mice

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Conversion of Bcl-2 to a Bax-like death effector by caspases

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Enhanced hydroxyl radical generation by 2'-methyl analog of MPTP: suppression by clorgyline and deprenyl

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Delayed movement disorders after carbon monoxide poisoning

1 reference

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7 January 2021

Characterization of MPP(+)-induced cell death in a dopaminergic neuronal cell line: role of macromolecule synthesis, cytosolic calcium, caspase, and Bcl-2-related proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

A one-hit model of cell death in inherited neuronal degenerations

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Developmental cell death: morphological diversity and multiple mechanisms

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Modulation of cell death by Bcl-XL through caspase interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

The iap genes: unique arbitrators of cell death

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Control of programmed cell death by the baculovirus genes p35 and iap.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Global cerebral ischemia activates nuclear factor-kappa B prior to evidence of DNA fragmentation.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Deprenyl suppresses the oxidant stress associated with increased dopamine turnover

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Caspases: the executioners of apoptosis

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7 January 2021

Beta-carboline analogues of N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP): endogenous factors underlying idiopathic parkinsonism?

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

L-DOPA-induced neurotoxic and apoptotic changes on cultured chromaffin cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Mass fragmentography of dopamine and 6-hydroxydopamine. Application to the determination of dopamine in human brain biopsies from the caudate nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Caspase inhibition protects nigral neurons against 6-OHDA-induced retrograde degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Evidence for neuromelanin involvement in MPTP-induced neurotoxicity

1 reference

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7 January 2021

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

The involvement of p53 in dopamine-induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Glutathione peroxidase, glial cells and Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Long-term effect of MPTP in the mouse brain in relation to aging: neurochemical and immunocytochemical analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Oxidation and nitration of catecholamines by nitrogen oxides derived from nitric oxide.

1 reference

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7 January 2021

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1 reference

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7 January 2021

Effect of 6-hydroxydopamine on polymerization of tubulin. Protection by superoxide dismutase, catalase, or anaerobic conditions.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Determination of the (R)- and (S)-enantiomers of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid chromatographic column

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Mitochondria as the central control point of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Correlation between 1-methyl-4-phenylpyridinium ion (MPP+) levels, ascorbic acid oxidation and glutathione levels in the striatal synaptosomes of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated rat

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Role of oxidative stress in the manganese and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced apoptosis in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Endogenous inhibitors of caspases

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Decreased ferritin levels in brain in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

A cytoplasmic inhibitor of the JNK signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) cause rapid ATP depletion in isolated hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Bcl-Xshort is elevated following severe global ischemia in rat brains.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Caspase-3-like proteases and 6-hydroxydopamine induced neuronal cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Signal transduction pathways that regulate cell survival and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Human IAP-like protein regulates programmed cell death downstream of Bcl-xL and cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Genetic control of programmed cell death in the nematode C. elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Mechanisms and Functions of Cell Death

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7 January 2021

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

The history of parkinsonism

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

The oxidant stress hypothesis in Parkinson's disease: evidence supporting it

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Characterization and time course of MPP+ -induced apoptosis in human SH-SY5Y neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Autoradiographic localization and density of [125I]ferrotransferrin binding sites in the basal ganglia of control subjects, patients with Parkinson's disease and MPTP-lesioned monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

A Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Ageing and Parkinson's disease: substantia nigra regional selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Lactoferrin is synthesized by mouse brain tissue and its expression is enhanced after MPTP treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Pre- and postsynaptic neurotoxic effects of dopamine demonstrated by intrastriatal injection.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

An electron microscopic study of MPTP-induced inclusion bodies in an old monkey

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Selective role of glutathione in protecting human neuronal cells from dopamine-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Manganese catalyzed auto-oxidation of dopamine to 6-hydroxydopamine in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

A susceptibility locus for Parkinson's disease maps to chromosome 2p13.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Clastogenic and mutagenic actions of active species generated in the 6-hydroxydopamine/oxygen reaction: effects of scavengers of active oxygen, iron, and metal chelating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian syndrome in Macaca fascicularis: which midbrain dopaminergic neurons are lost?

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Nature of inhibition of mitochondrial respiratory complex I by 6-Hydroxydopamine

1 reference

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7 January 2021

Mechanism of inhibition of mitochondrial respiratory complex I by 6-hydroxydopamine and its prevention by desferrioxamine.

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7 January 2021

Young-onset Parkinson's disease: a clinical review

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7 January 2021

Lewy Bodies of Parkinson's Disease Contain Neurofilament Antigens

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7 January 2021

Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study

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7 January 2021

Effect of 6-hydroxydopamine on murine hematopoietic stem cells: enhanced cytotoxicity on megakaryocyte colony forming units

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7 January 2021

Subdivisional involvement of nigrostriatal loop in idiopathic Parkinson's disease and striatonigral degeneration

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7 January 2021

The central executioners of apoptosis: caspases or mitochondria?

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7 January 2021

Apoptotic pathways: the roads to ruin

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7 January 2021

Mitochondria and apoptosis

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7 January 2021

The brain-stem lesions in Parkinsonism

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7 January 2021

Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation.

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7 January 2021

Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway

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7 January 2021

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

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7 January 2021

Transcription factor ATF2 regulation by the JNK signal transduction pathway

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7 January 2021

Selective interaction of JNK protein kinase isoforms with transcription factors

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7 January 2021

MRI, brain iron and experimental Parkinson's disease

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7 January 2021

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

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7 January 2021

Stable parkinsonian syndrome and uneven loss of striatal dopamine fibres following chronic MPTP administration in baboons.

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7 January 2021

Modeling dopamine system dysfunction in experimental animals.

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7 January 2021

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

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7 January 2021

Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells.

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7 January 2021

Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease

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7 January 2021

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

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7 January 2021

Increase in bax expression in substantia nigra following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of mice.

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7 January 2021

Identification of catechol-protein conjugates in neostriatal slices incubated with [3H]dopamine: impact of ascorbic acid and glutathione

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7 January 2021

Intrastriatal injection of dopamine results in DNA damage and apoptosis in rats.

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7 January 2021

Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease.

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7 January 2021

Increased iron in the substantia nigra of 6-OHDA induced parkinsonian rats: a nuclear microscopy study.

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7 January 2021

6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra

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7 January 2021

Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effect of amphetamine, apomorphine, and DOPA

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7 January 2021

Inhibition of Biogenic Amine Uptake by Hydrogen Peroxide: A Mechanism for Toxic Effects of 6-Hydroxydopamine

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7 January 2021

Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity.

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7 January 2021

Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse

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7 January 2021

Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

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7 January 2021

Programmed cell death in Caenorhabditis elegans

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7 January 2021

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

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7 January 2021

Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.

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7 January 2021

Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo

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7 January 2021

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

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7 January 2021

Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis

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7 January 2021

Neuronal vulnerability in Parkinson's disease.

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7 January 2021

Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice

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7 January 2021

Mechanisms of dopamine-induced cell death in cultured rat forebrain neurons: interactions with and differences from glutamate-induced cell death

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7 January 2021

Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

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7 January 2021

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

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7 January 2021

A clinicopathologic study of 100 cases of Parkinson's disease

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7 January 2021

Nitric oxide synthase and neuronal vulnerability in Parkinson's disease.

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7 January 2021

Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease

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7 January 2021

Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death

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7 January 2021

1-methyl-4-phenyl-pyridinium ion (MPP+) causes DNA fragmentation and increases the Bcl-2 expression in human neuroblastoma, SH-SY5Y cells, through different mechanisms

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7 January 2021

Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

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7 January 2021

Programmed cell death in animal development

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7 January 2021

Dopamine and glutamate neurotoxicity in cultured chick telencephali cells: effects of NMDA antagonists, antioxidants and MAO inhibitors.

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7 January 2021

Mitochondrial membrane permeabilization during the apoptotic process

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7 January 2021

Age-dependent effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP).

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7 January 2021

Iron-melanin complex in substantia nigra of parkinsonian brains: an x-ray microanalysis

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7 January 2021

Cell death mechanisms in Parkinson's disease

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7 January 2021

Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson's Disease Research Group

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7 January 2021

6-Hydroxydopamine lesion of the rat substantia nigra: time course and morphology of cell death

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7 January 2021

Activation of caspase-3 in developmental models of programmed cell death in neurons of the substantia nigra.

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7 January 2021

Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects.

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7 January 2021

Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation.

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7 January 2021

Evidence for involvement of Bax and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons.

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7 January 2021

Dopamine-induced apoptosis is mediated by oxidative stress and Is enhanced by cyanide in differentiated PC12 cells

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7 January 2021

Effects of 6-hydroxydopamine on the uptake and storage of noradrenaline in sympathetic adrenergic neurons

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7 January 2021

Quantitation of fluorescence of biogenic monoamines demonstrated with the formaldehyde flourescence method

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7 January 2021

Uptake and accumulation of 3H-6-hydroxydopamine in adrenergic nerves

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7 January 2021

Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease

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7 January 2021

Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons

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7 January 2021

Activation of c-jun N-terminal kinase/stress-activated protein kinase and the decreased ratio of Bcl-2 to Bax are associated with the auto-oxidized dopamine-induced apoptosis in PC12 cells

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7 January 2021

JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?

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7 January 2021

Absence of 6-hydroxydopamine in the rat brain after treatment with stimulants and other dopaminergic agents: a mass fragmentographic study

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7 January 2021

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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7 January 2021

Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury.

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7 January 2021

DNA fragmentation in human substantia nigra: apoptosis or perimortem effect?

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7 January 2021

Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

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7 January 2021

Glutathione peroxidase activity in Parkinson's disease brain.

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7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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7 January 2021

Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells.

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7 January 2021

Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity.

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7 January 2021

Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

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7 January 2021

Ca2+-mediated activation of c-Jun N-terminal kinase and nuclear factor kappa B by NMDA in cortical cell cultures.

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7 January 2021

On the question of apoptosis in the parkinsonian substantia nigra

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7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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7 January 2021

Free radical-generated neurotoxicity of 6-hydroxydopamine

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7 January 2021

Pretreatment with nimodipine prevents MPTP-induced neurotoxicity at the nigral, but not at the striatal level in mice

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7 January 2021

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in non-human primates is antagonized by pretreatment with nimodipine at the nigral, but not at the striatal level.

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7 January 2021

The inflammatory reaction following 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine intoxication in mouse.

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7 January 2021

Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study.

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7 January 2021

The stress-activated protein kinase subfamily of c-Jun kinases

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7 January 2021

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

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7 January 2021

Effects of MPTP, MPP+ and paraquat on mitochondrial potential and oxidative stress

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7 January 2021

Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice

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7 January 2021

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

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7 January 2021

Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons

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7 January 2021

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

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7 January 2021

(-)-Deprenyl protection of 1-methyl-4 phenylpyridium ion (MPP+)-induced apoptosis independent of MAO-B inhibition

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7 January 2021

Clinical observations on the rate of progression of idiopathic parkinsonism

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7 January 2021

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

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7 January 2021

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

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7 January 2021

Antiapoptotic role of NF-kappaB in the auto-oxidized dopamine-induced apoptosis of PC12 cells

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7 January 2021

1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis.

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7 January 2021

Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death

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7 January 2021

Detection of dopamine--DNA adducts: potential role in Parkinson's disease

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7 January 2021

Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases

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7 January 2021

p53, the cellular gatekeeper for growth and division

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7 January 2021

Deciphering the pathways of life and death

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7 January 2021

N-acetyl-serotonin (normelatonin) and melatonin protect neurons against oxidative challenges and suppress the activity of the transcription factor NF-kappaB.

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7 January 2021

High constitutive NF-kappaB activity mediates resistance to oxidative stress in neuronal cells.

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7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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7 January 2021

Thalamic, subthalamic nucleus and internal pallidum stimulation in Parkinson's disease

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7 January 2021

Dopamine, 6-hydroxydopamine, iron, and dioxygen--their mutual interactions and possible implication in the development of Parkinson's disease

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7 January 2021

Janus faces of NF-kappa B: neurodestruction versus neuroprotection

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7 January 2021

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

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7 January 2021

Status epilepticus induces p53 sequence-specific DNA binding in mature rat brain.

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7 January 2021

Autoradiographic demonstration of uptake and accumulation of3H-6-hydroxydopamine in adrenergic nerves

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7 January 2021

The mitochondrion in cell death control: certainties and incognita

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7 January 2021

Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death

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7 January 2021

Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons.

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7 January 2021

Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodie

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7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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7 January 2021

Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway

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7 January 2021

Intrastriatal dopamine injection induces apoptosis through oxidation-involved activation of transcription factors AP-1 and NF-kappaB in rats.

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7 January 2021

Rate of cell death in parkinsonism indicates active neuropathological process

1 reference

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7 January 2021

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1 reference

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7 January 2021

Toxicity of Dopamine to Striatal Neurons In Vitro and Potentiation of Cell Death by a Mitochondrial Inhibitor

1 reference

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7 January 2021

Amine-mediated toxicity. The effects of dopamine, norepinephrine, 5-hydroxytryptamine, 6-hydroxydopamine, ascorbate, glutathione and peroxide on the in vitro activities of creatine and adenylate kinases in the brain of the rat.

1 reference

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7 January 2021

The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells.

1 reference

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7 January 2021

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway

1 reference

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7 January 2021

Upregulation of the anti-apoptotic protein Bcl-2 may be an early event in neurodegeneration: studies on Parkinson's and incidental Lewy body disease

1 reference

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7 January 2021

Early developmental destruction of terminals in the striatal target induces apoptosis in dopamine neurons of the substantia nigra.

1 reference

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7 January 2021

Apoptosis. Key to the mitochondrial gate

1 reference

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7 January 2021

Parkinson's disease in a nationwide twin cohort

1 reference

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7 January 2021

N-methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: in vivo microdialysis study.

1 reference

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7 January 2021

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

1 reference

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7 January 2021

An endogenous dopaminergic neurotoxin: implication for Parkinson's disease

1 reference

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7 January 2021

Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.

1 reference

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7 January 2021

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

1 reference

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7 January 2021

Melatonin prevents apoptosis induced by 6-hydroxydopamine in neuronal cells: implications for Parkinson's disease.

1 reference

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7 January 2021

Ultrastructural confirmation of neuronal protection by melatonin against the neurotoxin 6-hydroxydopamine cell damage

1 reference

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7 January 2021

Levodopa toxicity and apoptosis

1 reference

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7 January 2021

Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease

1 reference

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7 January 2021

Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in culture.

1 reference

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7 January 2021

An exegesis of IAPs: salvation and surprises from BIR motifs

1 reference

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7 January 2021

p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

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7 January 2021

Inhibition of ATP synthesis by 1-methyl-4-phenylpyridinium ion (MPP+) in isolated mitochondria from mouse brains.

1 reference

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7 January 2021

Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity by 1-methyl-4-phenylpyridinium ion

1 reference

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7 January 2021

Studies on the toxicity of 1-methyl-4-phenylpyridinium ion (MPP+) against mitochondria of mouse brain

1 reference

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7 January 2021

Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

1 reference

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7 January 2021

Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat.

1 reference

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7 January 2021

Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys.

1 reference

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7 January 2021

Histochemical detection of apoptosis in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Genetic toxicity of dopamine.

1 reference

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7 January 2021

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Effect of dopamine, dimethoxyphenylethylamine, papaverine, and related compounds on mitochondrial respiration and complex I activity

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

An induced proximity model for caspase-8 activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl(R)salsolinol.

1 reference

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7 January 2021

New Reaction Pathways of Dopamine under Oxidative Stress Conditions: Nonenzymatic Iron-Assisted Conversion to Norepinephrine and the Neurotoxins 6-Hydroxydopamine and 6,7-Dihydroxytetrahydroisoquinoline

1 reference

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7 January 2021

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1 reference

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7 January 2021

Caspases: killer proteases

1 reference

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7 January 2021

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.

1 reference

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7 January 2021

Expression of c-Jun in dopaminergic neurons of the substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice.

1 reference

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7 January 2021

Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains

1 reference

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7 January 2021

Caspases: the proteases of the apoptotic pathway

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7 January 2021

Linking extracellular survival signals and the apoptotic machinery

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7 January 2021

Apoptosis and autoimmune disease.

1 reference

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7 January 2021

Caspases Mediate 6-Hydroxydopamine-Induced Apoptosis but Not Necrosis in PC12 Cells

1 reference

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7 January 2021

Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study

1 reference

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7 January 2021

Dopamine-induced programmed cell death in mouse thymocytes

1 reference

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7 January 2021

Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease.

1 reference

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7 January 2021

Dopamine-induced apoptosis is inhibited in PC12 cells expressing Bcl-2

1 reference

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7 January 2021

Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Overexpression of Bcl-2 attenuates MPP+, but not 6-ODHA, induced cell death in a dopaminergic neuronal cell line

1 reference

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7 January 2021

Sulfhydryl drugs reduce neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.

1 reference

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7 January 2021

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

1 reference

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7 January 2021

Genetic and functional changes in mitochondria associated with aging

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Fragile mitochondrial DNA: the missing link in the apoptotic neuronal cell death in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Nitrite- and Peroxide-Dependent Oxidation Pathways of Dopamine: 6-Nitrodopamine and 6-Hydroxydopamine Formation as Potential Contributory Mechanisms of Oxidative Stress- and Nitric Oxide-Induced Neurotoxicity in Neuronal Degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Activation of nuclear transcription factor kappa B (NF-kappaB) is essential for dopamine-induced apoptosis in PC12 cells

1 reference

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7 January 2021

Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Regional effects of 6-hydroxydopamine (6-OHDA) on free radical scavengers in rat brain

1 reference

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7 January 2021

Vitamin E attenuates the toxic effects of 6-hydroxydopamine on free radical scavenging systems in rat brain

1 reference

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7 January 2021

Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

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7 January 2021

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

1 reference

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7 January 2021

Nuclear factor-kappa B contributes to excitotoxin-induced apoptosis in rat striatum.

1 reference

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7 January 2021

Cell suicide for beginners

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7 January 2021

Bcl-2 family proteins

1 reference

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7 January 2021

Fate of nigrostriatal neurons in young mature mice given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: a neurochemical and morphological reassessment.

1 reference

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7 January 2021

Aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra

1 reference

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7 January 2021

Apoptosis: the germs of death

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7 January 2021

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

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7 January 2021

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1 reference

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

1 reference

7 January 2021

Changes in lipid peroxidation induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium in mouse brain homogenates

1 reference

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7 January 2021

Changes of metallothionein i + ii proteins in the brain after l-methyl-4-phenylpyridinium administration in mice

1 reference

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7 January 2021

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and free radicals in vitro

1 reference

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7 January 2021

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

1 reference

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7 January 2021

Bcl-2 family members in the development and degenerative pathologies of the nervous system

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7 January 2021

p53 induction is associated with neuronal damage in the central nervous system

1 reference

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7 January 2021

Monoamine oxidase B inhibitor selegiline protects young and aged rat peripheral sympathetic neurons against 6-hydroxydopamine-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Mitochondrial complex I deficiency in Parkinson's disease

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7 January 2021

Mitochondrial complex I deficiency in Parkinson's disease

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7 January 2021

Mitochondrial dysfunction in neurodegenerative disorders

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7 January 2021

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

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7 January 2021

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1

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7 January 2021

Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.

1 reference

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7 January 2021

Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Nuclear factor-kappa B activation in permanent intraluminal focal cerebral ischemia in the rat

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7 January 2021

Neuroblastoma cells expressing the noradrenaline transporter are destroyed more selectively by 6-fluorodopamine than by 6-hydroxydopamine

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Iron induces degeneration of nigrostriatal neurons

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Progressive changes in striatal dopaminergic markers, nigral volume, and rotational behavior following iron infusion into the rat substantia nigra

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Dose-dependent destruction of the coeruleus-cortical and nigral-striatal projections by MPTP.

1 reference

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7 January 2021

Mitochondrial DNA maintenance in vertebrates

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7 January 2021

MPP+ induced apoptotic cell death in SH-SY5Y neuroblastoma cells: an electron microscope study

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7 January 2021

The role of hydroxyl radical as a messenger in the activation of nuclear transcription factor NFKB

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7 January 2021

The effects of 6-hydroxydopamine and oxidative stress on the level of brain metallothionein

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7 January 2021

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Dopamine-induced apoptosis in human neuronal cells: inhibition by nucleic acids antisense to the dopamine transporter

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Increase in extracellular dopamine in the striatum during cerebral ischemia: a study utilizing cerebral microdialysis

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7 January 2021

Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease

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7 January 2021

MPP+ inhibits proliferation of PC12 cells by a p21(WAF1/Cip1)-dependent pathway and induces cell death in cells lacking p21(WAF1/Cip1)

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Boo, a novel negative regulator of cell death, interacts with Apaf-1.

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7 January 2021

Autoxidation and Neurotoxicity of 6-Hydroxydopamine in the Presence of Some Antioxidants

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7 January 2021

Alpha-synuclein in Lewy bodies

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7 January 2021

Dopamine turnover and glutathione oxidation: implications for Parkinson disease

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

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7 January 2021

Mechanisms and genes of cellular suicide

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7 January 2021

Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis

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7 January 2021

6-Hydroxydopamine toxicity towards human SH-SY5Y dopaminergic neuroblastoma cells: independent of mitochondrial energy metabolism

1 reference

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7 January 2021

1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism.

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

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7 January 2021

Mitogen-activated protein kinase cascades and regulation of gene expression

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7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Origin and functional consequences of the complex I defect in Parkinson's disease

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7 January 2021

Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family

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https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

1 reference

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7 January 2021

Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Parkinson disease in twins: an etiologic study

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental microanalysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Neurochemical lesioning in the rat brain with iontophoretic injection of the 1-methyl-4-phenylpyridinium ion (MPP+)

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Mild parkinsonism in persons exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-Hydroxydopamine

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Differential effects of staurosporine and retinoic acid on the vulnerability of the SH-SY5Y neuroblastoma cells: involvement of bcl-2 and p53 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Participation of active oxygen species in 6-hydroxydopamine toxicity to a human neuroblastoma cell line.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Bcl-2 and Bax proteins in Lewy bodies from patients with Parkinson's disease and Diffuse Lewy body disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Electronmicroscopic localization of 5-hydroxydopamine (3,4,5-trihydroxy-phenyl-ethylamine), a New ‘false’ sympathetic transmitter

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

An electron microscopic study of selective, acute degeneration of sympathetic nerve terminals after administration of 6-hydroxydopamine

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

6-Hydroxydopamine induces thymocyte apoptosis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

1 reference

7 January 2021

6-hydroxy-dopamine induced degeneration of central monoamine neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Effects of 6-hydroxydopamine on catecholamine containing neurones in the rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Pathological findings in idiopathic orthostatic hypotension. Its relationship with Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Chronic MPTP treatment reproduces in baboons the differential vulnerability of mesencephalic dopaminergic neurons observed in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Cell Death in Development

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Dopamine and iron induce apoptosis in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Rescue from death but not from functional impairment: caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Localization of damage induced by reactive oxygen species in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Expression of Bcl-2 in adult human brain regions with special reference to neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Effect of 6-hydroxydopamine on oxidative phosphorylation and on monoamine oxidase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. Implications for the treatment of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Life, death, and the pursuit of apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Dopamine: a novel antitumor agent active against B-16 melanoma in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Structure and mechanism of interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Cleavage of Bax enhances its cell death function

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

The toxicity of 6-hydroxydopamine on PC12 and P19 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Maternal inheritance in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Relationships between the mitochondrial transmembrane potential, ATP concentration, and cytotoxicity in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Unlike MPP+, apoptosis induced by 6-OHDA in PC12 cells is independent of mitochondrial inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Glutathione depletion potentiates MPTP and MPP+ toxicity in nigral dopaminergic neurones.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Cell death and apoptosis regulating proteins in Parkinson's disease--a cautionary note.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Bax involvement in p53-mediated neuronal cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Possible involvement of catalase in the protective effect of interleukin-6 against 6-hydroxydopamine toxicity in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Herpes simplex virus vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine-induced degeneration of neurons in the substantia nigra in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Apoptosis induction by a dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP(+)), and inhibition by epidermal growth factor in GH3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Transducing signals of life and death

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Mitochondrial control of nuclear apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Secondary excitotoxicity contributes to dopamine-induced apoptosis of dopaminergic neuronal cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Monoamine-induced apoptotic neuronal cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Dopamine induces apoptosis-like cell death in cultured chick sympathetic neurons--a possible novel pathogenetic mechanism in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Neuroprotection by pramipexole against dopamine- and levodopa-induced cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2801%2900003-X

7 January 2021

10.1016/S0301-0082(01)00003-X

Identifiers

DOI

1 reference

30 July 2017

1 reference