Apoptosis: checkpoint at the mitochondrial frontier. (Q33732630)

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31 October 2019

review article

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title

Apoptosis: checkpoint at the mitochondrial frontier (English)

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31 October 2019

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2

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31 October 2019

author name string

E Bossy-Wetzel

series ordinal

1

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31 October 2019

language of work or name

English

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publication date

1 July 1999

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31 October 2019

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31 October 2019

volume

434

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31 October 2019

page(s)

243-251

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31 October 2019

issue

3

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Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.

31 October 2019

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis

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Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

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Mitochondria and programmed cell death: back to the future.

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Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

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The mitochondrial permeability transition.

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Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

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Bcl-2 functions in an antioxidant pathway to prevent apoptosis

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Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

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Is apoptosis mediated by reactive oxygen species?

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Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death

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Cytochrome c: can't live with it--can't live without it.

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Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss

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Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts

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Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

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Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

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7 January 2021

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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7 January 2021

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

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7 January 2021

The ancient regulatory-protein family of WD-repeat proteins

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7 January 2021

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

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7 January 2021

Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

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7 January 2021

WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

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7 January 2021

Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release

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7 January 2021

Injected cytochrome c induces apoptosis

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7 January 2021

Blocking cytochrome c activity within intact neurons inhibits apoptosis.

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7 January 2021

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

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7 January 2021

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

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7 January 2021

Mitochondria and apoptosis

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7 January 2021

Induction of the mitochondrial permeability transition causes release of the apoptogenic factor cytochrome c

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7 January 2021

Apoptosis, in human monocytic THP.1 cells, results in the release of cytochrome c from mitochondria prior to their ultracondensation, formation of outer membrane discontinuities and reduction in inner membrane potential

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7 January 2021

Caspases disrupt mitochondrial membrane barrier function.

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7 January 2021

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

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7 January 2021

Cell death: the significance of apoptosis

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Inhibition of Bax channel-forming activity by Bcl-2

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7 January 2021

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

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Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

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7 January 2021

Bax directly induces release of cytochrome c from isolated mitochondria

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Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

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7 January 2021

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

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7 January 2021

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

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7 January 2021

Bcl-2-family proteins: the role of the BH3 domain in apoptosis.

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Bcl-2 and Bax function independently to regulate cell death

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7 January 2021

Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells

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7 January 2021

Bax-independent inhibition of apoptosis by Bcl-XL.

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7 January 2021

Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer

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7 January 2021

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

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7 January 2021

Movement of Bax from the cytosol to mitochondria during apoptosis

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7 January 2021

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

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7 January 2021

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

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7 January 2021

Channel formation by antiapoptotic protein Bcl-2.

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7 January 2021

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

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7 January 2021

The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells.

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7 January 2021

Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c

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7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

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7 January 2021

X-linked IAP is a direct inhibitor of cell-death proteases

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7 January 2021

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

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7 January 2021

Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

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7 January 2021

Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

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7 January 2021

Human IAP-like protein regulates programmed cell death downstream of Bcl-xL and cytochrome c

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7 January 2021

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

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7 January 2021

Pro-caspase-3 is a major physiologic target of caspase-8.

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7 January 2021

Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c.

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7 January 2021

A caspase-activated factor (CAF) induces mitochondrial membrane depolarization and cytochrome c release by a nonproteolytic mechanism.

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7 January 2021

Caspases induce cytochrome c release from mitochondria by activating cytosolic factors

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7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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7 January 2021

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

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7 January 2021

BID: a novel BH3 domain-only death agonist

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7 January 2021

Conversion of Bcl-2 to a Bax-like death effector by caspases

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7 January 2021

Modulation of cell death by Bcl-XL through caspase interaction

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7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

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7 January 2021

Caspase activity is required for commitment to Fas-mediated apoptosis.

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7 January 2021

Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

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7 January 2021

Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak

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7 January 2021

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

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7 January 2021

10.1016/S0921-8777(99)00032-4

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10486595%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

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