A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development (Q28589467)

CD5 antigen

1 reference

CD3 antigen, epsilon polypeptide

1 reference

Zeta-chain (TCR) associated protein kinase

1 reference

CD247 antigen

1 reference

Protein tyrosine phosphatase, receptor type, C

1 reference

CD8 antigen, alpha chain

1 reference

CD3 antigen, delta polypeptide

1 reference

CD4 antigen

1 reference

0 references

0 references

D. L. Wiest

1

1 reference

31 January 2017

J. M. Ashe

2

1 reference

31 January 2017

T. K. Howcroft

3

1 reference

31 January 2017

H. M. Lee

4

1 reference

31 January 2017

D. M. Kemper

5

1 reference

31 January 2017

I. Negishi

6

1 reference

31 January 2017

D. S. Singer

7

1 reference

31 January 2017

A. Singer

8

1 reference

31 January 2017

R. Abe

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

9

1 reference

31 January 2017

language of work or name

English

0 references

publication date

1 June 1997

1 reference

31 January 2017

1 reference

31 January 2017

6

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31 January 2017

663–671

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31 January 2017

6

1 reference

31 January 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Protein tyrosine kinases in the initiation of antigen receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen-Reactivity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

T cell activation by clustered tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Selective events in T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Differential T cell costimulatory requirements in CD28-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

F2(Pmp)2-TAM zeta 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Signal transduction by lymphocyte antigen receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980442-2

7 January 2021