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TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck (Q71079176)

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scientific article published on 01 May 1996

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English	TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck	scientific article published on 01 May 1996

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

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16 October 2019

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J M Ashe

2

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16 October 2019

R Abe

3

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16 October 2019

J B Bolen

4

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16 October 2019

A Singer

5

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16 October 2019

publication date

1 May 1996

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16 October 2019

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

4

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16 October 2019

5

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16 October 2019

495-504

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16 October 2019

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1 reference

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7 January 2021

based on heuristic

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Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction

1 reference

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7 January 2021

based on heuristic

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Another view of the selective model of thymocyte selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

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Mice lacking MHC class II molecules

1 reference

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7 January 2021

based on heuristic

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Identification of a murine monoclonal antibody specific for an allotypic determinant on mouse CD3

1 reference

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7 January 2021

based on heuristic

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Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

1 reference

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7 January 2021

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Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen-Reactivity

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

T cell activation by clustered tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a monoclonal antibody specific for a murine T3 polypeptide

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Profound block in thymocyte development in mice lacking p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective events in T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the components of the murine T cell antigen receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Distribution of H-2 microenvironments in the mouse thymus. Immunoelectron microscopic identification of I-A and H-2K bearing cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

F2(Pmp)2-TAM zeta 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of Zap-70 by Src family tyrosine protein kinases in an antigen-specific T-cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1074-7613(00)80415-X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

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