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Zeta-chain (TCR) associated protein kinase (Q14907114)

From Wikidata

mammalian protein found in Mus musculus

Zap70
70 kDa zeta-chain associated protein
tyrosine-protein kinase ZAP-70
syk-related tyrosine kinase

Language	Label	Description	Also known as
default for all languages	No label defined
English	Zeta-chain (TCR) associated protein kinase	mammalian protein found in Mus musculus	Zap70 70 kDa zeta-chain associated protein tyrosine-protein kinase ZAP-70 syk-related tyrosine kinase

Statements

1 reference

25 May 2022

UniProt protein ID

tyrosine-protein kinase, non-receptor SYK/ZAP-70

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43404

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43404

Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43404

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43404

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SYK/ZAP-70, N-terminal SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

nucleotide binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

non-membrane spanning protein tyrosine kinase activity

determination method or standard

kinase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

protein binding

determination method or standard

6 references

14 February 2019

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Lck availability during thymic selection determines the recognition specificity of the T cell repertoire

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

protein tyrosine kinase activity

determination method or standard

7 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Characterization of Lnk. An adaptor protein expressed in lymphocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

signaling receptor binding

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43404&geneProductId=UniProtKB:P43404

determination method or standard

determination method or standard

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

determination method or standard

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

cell-cell junction

determination method or standard

1 reference

14 February 2019

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

extrinsic component of cytoplasmic side of plasma membrane

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43404&geneProductId=UniProtKB:P43404

determination method or standard

plasma membrane

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

immunological synapse

determination method or standard

1 reference

14 February 2019

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

biological process

positive regulation of T cell differentiation

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

positive regulation of calcium-mediated signaling

determination method or standard

phosphorylation

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

transmembrane receptor protein tyrosine kinase signaling pathway

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43404&geneProductId=UniProtKB:P43404

determination method or standard

immune system process

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

determination method or standard

1 reference

14 February 2019

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

negative thymic T cell selection

determination method or standard

1 reference

14 February 2019

Essential role for ZAP-70 in both positive and negative selection of thymocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

protein phosphorylation

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Characterization of Lnk. An adaptor protein expressed in lymphocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

positive regulation of alpha-beta T cell proliferation

determination method or standard

1 reference

14 February 2019

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

positive thymic T cell selection

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Essential role for ZAP-70 in both positive and negative selection of thymocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

peptidyl-tyrosine autophosphorylation

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43404&geneProductId=UniProtKB:P43404

determination method or standard

protein autophosphorylation

determination method or standard

peptidyl-tyrosine phosphorylation

determination method or standard

5 references

14 February 2019

CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Interchangeability of Themis1 and Themis2 in Thymocyte Development Reveals Two Related Proteins with Conserved Molecular Function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

innate immune response

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43404&geneProductId=UniProtKB:P43404

determination method or standard

T cell receptor signaling pathway

determination method or standard

1 reference

14 February 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

thymic T cell selection

determination method or standard

1 reference

14 February 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

positive regulation of alpha-beta T cell differentiation

determination method or standard

3 references

14 February 2019

Essential role for ZAP-70 in both positive and negative selection of thymocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

14 February 2019

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

adaptive immune response

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

determination method or standard

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43404&geneProductId=UniProtKB:P43404

determination method or standard

tyrosine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43404

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43404

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43404

tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43404

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43404

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43404

SYK/ZAP-70, N-terminal SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43404

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000027291

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000027291

ENSMUSP00000139990

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000139990

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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