Zeta-chain (TCR) associated protein kinase (Q14907114)

Protein kinase-like domain superfamily

1 reference

Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily

1 reference

SH2 domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

SH2 domain, protein family

1 reference

SYK/ZAP-70, N-terminal SH2 domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

non-membrane spanning protein tyrosine kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

6 references

14 February 2019

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

Regulation of T cell development by the deubiquitinating enzyme CYLD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

Lck availability during thymic selection determines the recognition specificity of the T cell repertoire

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

protein tyrosine kinase activity

IPI

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

Characterization of Lnk. An adaptor protein expressed in lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

signaling receptor binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43404&geneProductId=UniProtKB:P43404

3 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

1 reference

14 February 2019

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

extrinsic component of cytoplasmic side of plasma membrane

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43404&geneProductId=UniProtKB:P43404

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

immunological synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

positive regulation of T cell differentiation

biological process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43404&geneProductId=UniProtKB:P43404

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

immune system process

1 reference

14 February 2019

1 reference

14 February 2019

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

negative thymic T cell selection

IGI

1 reference

14 February 2019

Essential role for ZAP-70 in both positive and negative selection of thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

IMP

protein phosphorylation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

Characterization of Lnk. An adaptor protein expressed in lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

positive regulation of alpha-beta T cell proliferation

1 reference

14 February 2019

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

positive thymic T cell selection

IGI

3 references

peptidyl-tyrosine autophosphorylation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43404&geneProductId=UniProtKB:P43404

peptidyl-tyrosine phosphorylation

5 references

14 February 2019

CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43404&geneProductId=UniProtKB:P43404

innate immune response

1 reference

24 April 2018

T cell receptor signaling pathway

1 reference

14 February 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

IMP

thymic T cell selection

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

positive regulation of alpha-beta T cell differentiation

IMP

3 references

14 February 2019

Essential role for ZAP-70 in both positive and negative selection of thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

14 February 2019

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43404

IGI

adaptive immune response

1 reference

14 February 2019

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43404&geneProductId=UniProtKB:P43404

tyrosine-protein kinase, active site

has part(s)

1 reference

protein kinase, ATP binding site

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

protein kinase domain

1 reference

SH2 domain

1 reference

SYK/ZAP-70, N-terminal SH2 domain

1 reference