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CD3 antigen, epsilon polypeptide (Q21981008)

From Wikidata

mammalian protein found in Mus musculus

Cd3e
T-cell surface glycoprotein CD3 epsilon chain
T-cell surface antigen T3/Leu-4 epsilon chain

Language	Label	Description	Also known as
default for all languages	No label defined
English	CD3 antigen, epsilon polypeptide	mammalian protein found in Mus musculus	Cd3e T-cell surface glycoprotein CD3 epsilon chain T-cell surface antigen T3/Leu-4 epsilon chain

Statements

1 reference

25 May 2022

UniProt protein ID

CD3 protein, epsilon/gamma/delta subunit

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22646

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22646

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22646

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Immunoglobulin subtype 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphorylated immunoreceptor signalling ITAM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

signal transducer activity

determination method or standard

1 reference

4 April 2017

Essential role for ZAP-70 in both positive and negative selection of thymocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

transmembrane signaling receptor activity

determination method or standard

1 reference

4 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

protein binding

determination method or standard

1 reference

8 April 2019

Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

cell-cell junction

determination method or standard

1 reference

8 April 2019

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

alpha-beta T cell receptor complex

determination method or standard

plasma membrane

determination method or standard

external side of plasma membrane

determination method or standard

14 references

4 April 2017

FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

Interchangeability of Themis1 and Themis2 in Thymocyte Development Reveals Two Related Proteins with Conserved Molecular Function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

Essential role for ZAP-70 in both positive and negative selection of thymocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

plasma membrane

determination method or standard

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

CD3 and immunoglobulin G Fc receptor regulate cerebellar functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

external side of plasma membrane

determination method or standard

15 references

8 April 2019

FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Essential role for ZAP-70 in both positive and negative selection of thymocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Interchangeability of Themis1 and Themis2 in Thymocyte Development Reveals Two Related Proteins with Conserved Molecular Function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

alpha-beta T cell receptor complex

determination method or standard

3 references

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

dendritic spine

determination method or standard

1 reference

8 April 2019

CD3 and immunoglobulin G Fc receptor regulate cerebellar functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

determination method or standard

1 reference

8 April 2019

CD3 and immunoglobulin G Fc receptor regulate cerebellar functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

biological process

lymphocyte activation

determination method or standard

1 reference

8 April 2019

Negative regulation of lymphocyte activation by the adaptor protein LAX

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

T cell costimulation

determination method or standard

1 reference

8 April 2019

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

T cell differentiation in thymus

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

positive regulation of alpha-beta T cell proliferation

determination method or standard

3 references

8 April 2019

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

positive regulation of interferon-gamma production

determination method or standard

1 reference

8 April 2019

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

positive regulation of interleukin-4 production

determination method or standard

1 reference

8 April 2019

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

positive regulation of T cell anergy

determination method or standard

1 reference

8 April 2019

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

cell surface receptor signaling pathway

determination method or standard

3 references

4 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

Enhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

4 April 2017

Essential role for ZAP-70 in both positive and negative selection of thymocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

positive regulation of peptidyl-tyrosine phosphorylation

determination method or standard

1 reference

8 April 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

negative regulation of smoothened signaling pathway

determination method or standard

1 reference

8 April 2019

Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

apoptotic signaling pathway

determination method or standard

1 reference

8 April 2019

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

positive regulation of T cell activation

determination method or standard

1 reference

8 April 2019

Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

T cell receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

immune system process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

negative thymic T cell selection

determination method or standard

1 reference

8 April 2019

Essential role for ZAP-70 in both positive and negative selection of thymocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

positive regulation of T cell proliferation

determination method or standard

6 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

response to nutrient

determination method or standard

1 reference

4 April 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

determination method or standard

positive regulation of cell-matrix adhesion

determination method or standard

1 reference

8 April 2019

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

adaptive immune response

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

cell surface receptor signaling pathway

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Enhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Essential role for ZAP-70 in both positive and negative selection of thymocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

response to nutrient

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

dendrite development

determination method or standard

1 reference

8 April 2019

CD3 and immunoglobulin G Fc receptor regulate cerebellar functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

cerebellum development

determination method or standard

1 reference

8 April 2019

CD3 and immunoglobulin G Fc receptor regulate cerebellar functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

T cell differentiation

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

positive regulation of cell-cell adhesion mediated by integrin

determination method or standard

1 reference

8 April 2019

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

positive thymic T cell selection

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

determination method or standard

Phosphorylated immunoreceptor signalling ITAM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22646

immunoglobulin subtype 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22646

immunoglobulin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22646

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000099896

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000099896

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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