Protein tyrosine phosphatase, receptor type, C (Q21985631)

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mammalian protein found in Mus musculus
  • Ly-5
  • Ptprc
  • lymphocyte antigen 5
  • receptor-type tyrosine-protein phosphatase C
  • L-CA
  • T200
  • lymphocyte common antigen
  • leukocyte common antigen
edit
Language Label Description Also known as
English
Protein tyrosine phosphatase, receptor type, C
mammalian protein found in Mus musculus
  • Ly-5
  • Ptprc
  • lymphocyte antigen 5
  • receptor-type tyrosine-protein phosphatase C
  • L-CA
  • T200
  • lymphocyte common antigen
  • leukocyte common antigen

Statements

molecular function
protein tyrosine phosphatase activity
determination method
IDA
ISS
IEA
ISO
8 references
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P06800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
ISS
retrieved
16 July 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
ISO
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P06800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IEA
retrieved
16 July 2018
stated in
Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
16 July 2018
stated in
Detection of restricted isoform expression and tyrosine phosphatase activity of CD45 in murine dendritic cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
16 July 2018
stated in
Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
protein tyrosine phosphatase activity
determination method
IDA
IEA
IGI
ISO
ISS
9 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P06800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
ISO
retrieved
8 April 2019
stated in
CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P06800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IEA
retrieved
8 April 2019
stated in
Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
8 April 2019
stated in
Detection of restricted isoform expression and tyrosine phosphatase activity of CD45 in murine dendritic cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
8 April 2019
stated in
Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
protein tyrosine phosphatase activity
determination method
IBA
IDA
IEA
IGI
ISO
ISS
10 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P06800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
ISS
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
ISO
retrieved
9 May 2019
stated in
CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IGI
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P06800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IEA
retrieved
9 May 2019
stated in
Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Detection of restricted isoform expression and tyrosine phosphatase activity of CD45 in murine dendritic cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IBA
cell component
external side of plasma membrane
determination method
IDA
ISO
44 references
retrieved
24 April 2018
stated in
FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
ISO
retrieved
24 April 2018
stated in
Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
GATA-3 is required for early T lineage progenitor development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Essential role for ZAP-70 in both positive and negative selection of thymocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Detection of restricted isoform expression and tyrosine phosphatase activity of CD45 in murine dendritic cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Differential T cell costimulatory requirements in CD28-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Accessory protein-like is essential for IL-18-mediated signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Immunological properties of murine thymus-dependent lymphocyte surface glycoproteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Generation of T cells with differential responses to alloantigens in CD45 exon 6-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Cholinergic chemosensory cells in the trachea regulate breathing
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Transgenic major histocompatibility complex class I antigen expressed in mouse trophoblast affects maternal immature B cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
miR-181b negatively regulates activation-induced cytidine deaminase in B cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Syk tyrosine kinase required for mouse viability and B-cell development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
24 April 2018
stated in
Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06800&geneProductId=UniProtKB:P06800
determination method
IDA
external side of plasma membrane
determination method
IDA
IEA
ISO
44 references
retrieved
9 May 2019
stated in
FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
ISO
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IEA
retrieved
9 May 2019
stated in
Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Syk tyrosine kinase required for mouse viability and B-cell development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Generation of T cells with differential responses to alloantigens in CD45 exon 6-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Cholinergic chemosensory cells in the trachea regulate breathing
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Transgenic major histocompatibility complex class I antigen expressed in mouse trophoblast affects maternal immature B cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Accessory protein-like is essential for IL-18-mediated signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
GATA-3 is required for early T lineage progenitor development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
miR-181b negatively regulates activation-induced cytidine deaminase in B cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Immunological properties of murine thymus-dependent lymphocyte surface glycoproteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Essential role for ZAP-70 in both positive and negative selection of thymocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Differential T cell costimulatory requirements in CD28-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
retrieved
9 May 2019
stated in
CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IDA
biological process
B cell differentiation
determination method
IMP
5 references
retrieved
9 May 2019
stated in
Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IMP
retrieved
9 May 2019
stated in
The motheaten mutation rescues B cell signaling and development in CD45-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IMP
retrieved
9 May 2019
stated in
CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IMP
retrieved
9 May 2019
stated in
Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IMP
retrieved
9 May 2019
stated in
Phenotypical and functional alterations in the mucosal immune system of CD45 exon 9 KO mice
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IMP
positive regulation of B cell proliferation
determination method
IEA
IMP
ISO
6 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
ISO
retrieved
9 May 2019
stated in
Differential requirements of CD45 for lymphocyte development and function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IMP
retrieved
9 May 2019
stated in
The motheaten mutation rescues B cell signaling and development in CD45-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IMP
retrieved
9 May 2019
stated in
T-cell-independent antiviral B cell responses in CD45-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IMP
retrieved
9 May 2019
stated in
CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06800
determination method
IEA

Identifiers

 
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