Integrating cell-signalling pathways with NF-kappaB and IKK function (Q28280069)

Nature Reviews Molecular Cell Biology

Europe PubMed Central

title

Integrating cell-signalling pathways with NF-kappaB and IKK function (English)

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Neil D Perkins

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language of work or name

English

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publication date

January 2007

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published in

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volume

8

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page(s)

49-62

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issue

1

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cites work

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Good cop, bad cop: the different faces of NF-kappaB

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The IKK NF-kappa B system: a treasure trove for drug development

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NF-kappaB and IKK as therapeutic targets in cancer

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Nuclear factor-kappaB: its role in health and disease

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Genetic analysis of NF- B/Rel transcription factors defines functional specificities

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Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

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Oncogenes, tumor suppressors and p52 NF-κB

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Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome

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Chemical approaches to angiogenesis

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The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner

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Ubiquitin signalling in the NF-kappaB pathway

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A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways

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Inflammatory diseases: is ubiquitinated NEMO at the hub?

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Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

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Signals from within: the DNA-damage-induced NF-kappaB response

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Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli

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IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy

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To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis

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IKK mediates ischemia-induced neuronal death

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IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells

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IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

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Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin

31 March 2020

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Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

31 March 2020

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Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.

31 March 2020

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Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1.

31 March 2020

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Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.

31 March 2020

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Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.

31 March 2020

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IkappaB kinase is an essential component of the Tpl2 signaling pathway

31 March 2020

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A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

31 March 2020

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Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.

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Casper/c-FLIP is physically and functionally associated with NF-kappaB1 p105.

31 March 2020

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Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105

31 March 2020

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IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation

31 March 2020

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The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition

31 March 2020

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p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1.

31 March 2020

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Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase

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Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation

31 March 2020

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IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.

31 March 2020

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IKKalpha stabilizes cytosolic beta-catenin by inhibiting both canonical and non-canonical degradation pathways

31 March 2020

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Regulation of beta-catenin function by the IkappaB kinases

31 March 2020

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beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer

31 March 2020

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Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes

31 March 2020

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IkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylation

31 March 2020

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IKK alpha regulates estrogen-induced cell cycle progression by modulating E2F1 expression

31 March 2020

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SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival

31 March 2020

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IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9

31 March 2020

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A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

31 March 2020

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Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression

31 March 2020

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MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14

31 March 2020

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The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation.

31 March 2020

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p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment

31 March 2020

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IKKalpha controls formation of the epidermis independently of NF-kappaB.

31 March 2020

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A dual role for Ikk alpha in tooth development

31 March 2020

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Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression

31 March 2020

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Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator

31 March 2020

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An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4

31 March 2020

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The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

31 March 2020

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Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53

31 March 2020

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Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors

31 March 2020

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Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression

31 March 2020

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Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

31 March 2020

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IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300.

31 March 2020

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Shaping the nuclear action of NF-kappaB

31 March 2020

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p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

31 March 2020

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Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

31 March 2020

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Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation

31 March 2020

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Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

31 March 2020

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Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome.

31 March 2020

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NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta

31 March 2020

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cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B.

31 March 2020

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31 March 2020

Putting the rap on Akt.

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Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

31 March 2020

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Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells

31 March 2020

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IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines

31 March 2020

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Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import

31 March 2020

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p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.

31 March 2020

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IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

31 March 2020

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Achieving transcriptional specificity with NF-kappa B.

31 March 2020

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Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time

31 March 2020

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31 March 2020

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Reversal of intrinsic DNA bends in the IFN beta gene enhancer by transcription factors and the architectural protein HMG I(Y)

31 March 2020

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Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome

31 March 2020

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Inhibition of the RelA(p65) NF-kappaB subunit by Egr-1.

31 March 2020

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Shaping alternative NF-kappaB-dependent gene expression programs: new clues to specificity.

31 March 2020

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Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases

31 March 2020

1 reference

Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit

31 March 2020

1 reference

Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation

31 March 2020

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Acetylation of Stat1 modulates NF-kappaB activity

31 March 2020

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A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity

31 March 2020

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Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription

31 March 2020

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Mechanism of rapid transcriptional induction of tumor necrosis factor alpha-responsive genes by NF-kappaB.

31 March 2020

1 reference

Dorsal gradient networks in the Drosophila embryo

31 March 2020

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NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway

31 March 2020

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

31 March 2020

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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

31 March 2020

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

31 March 2020

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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

31 March 2020

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Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

31 March 2020

1 reference

The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.

31 March 2020

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Stimulus specificity of gene expression programs determined by temporal control of IKK activity

31 March 2020

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Achieving stability of lipopolysaccharide-induced NF-kappaB activation

31 March 2020

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Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa.

31 March 2020

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The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease

31 March 2020

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Reactive oxygen species mediate crosstalk between NF-kappaB and JNK.

31 March 2020

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Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

31 March 2020

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CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control

31 March 2020

1 reference

Live or let die: the cell's response to p53

31 March 2020

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p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy

31 March 2020

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Expression of the Bcl-3 proto-oncogene suppresses p53 activation

31 March 2020

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Transcriptional cross talk between NF-kappaB and p53.

31 March 2020

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Role of NF-κB in p53-mediated programmed cell death

31 March 2020

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Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.

31 March 2020

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Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.

31 March 2020

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Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1.

31 March 2020

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p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress

31 March 2020

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Nuclear receptors versus inflammation: mechanisms of transrepression

31 March 2020

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The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression

31 March 2020

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Update on glucocorticoid action and resistance

31 March 2020

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Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

31 March 2020

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Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids

31 March 2020

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Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1.

31 March 2020

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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

31 March 2020

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Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.

31 March 2020

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The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.

31 March 2020

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Molecular targets of dietary agents for prevention and therapy of cancer

31 March 2020

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Molecular diagnosis of lymphoid malignancies by gene expression profiling

31 March 2020

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The nuclear factor kappaB subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation.

31 March 2020

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The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer

31 March 2020

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Distinct domains of IkappaB-alpha inhibit human immunodeficiency virus type 1 replication through NF-kappaB and Rev.

31 March 2020

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Identifiers

DOI

10.1038/NRM2083

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

846568

1041332849

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846568

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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