NF-kappaB and IKK as therapeutic targets in cancer (Q28297985)

Cell Death & Differentiation

Europe PubMed Central

title

NF-kappaB and IKK as therapeutic targets in cancer (English)

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1 reference

H J Kim

1

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N Hawke

series ordinal

2

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A S Baldwin

series ordinal

3

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language of work or name

English

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publication date

May 2006

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published in

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volume

13

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page(s)

738-47

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issue

5

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cites work

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IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

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The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

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Nucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosis

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21 April 2017

Signaling to NF-kappaB

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IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

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NF-kappaB functions as a tumour promoter in inflammation-associated cancer

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Smoldering and polarized inflammation in the initiation and promotion of malignant disease

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NF-kappaB in cancer: from innocent bystander to major culprit

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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PI 3-kinase, Akt and cell survival

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At the crossroads of inflammation and cancer

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Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes

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Molecular sequelae of proteasome inhibition in human multiple myeloma cells

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The nuclear factor kappaB subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation.

21 January 2018

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MEK kinase 1 mediates the antiapoptotic effect of the Bcr-Abl oncogene through NF-κB activation

21 January 2018

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Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B.

21 January 2018

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Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity

21 January 2018

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Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation

21 January 2018

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Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

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Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells

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Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

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Transcriptional cross talk between NF-kappaB and p53.

21 January 2018

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NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

21 January 2018

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NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK.

21 January 2018

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Role of NF-κB in p53-mediated programmed cell death

21 January 2018

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p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy

21 January 2018

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beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer

21 January 2018

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Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.

21 January 2018

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IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy

21 January 2018

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Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta

21 January 2018

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NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

21 January 2018

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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

21 January 2018

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Thalidomide in newly diagnosed multiple myeloma and overview of experience in smoldering/indolent disease

21 January 2018

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Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications

21 January 2018

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Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity

21 January 2018

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Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM).

21 January 2018

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Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of Velcade (PS-341/bortezomib) cytotoxicity in myeloma cell lines

21 January 2018

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Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications.

21 January 2018

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Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis

21 January 2018

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Anti-proliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro

21 January 2018

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Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines

21 January 2018

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Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells.

21 January 2018

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Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis

21 January 2018

1 reference

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In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis.

21 January 2018

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Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs

21 January 2018

1 reference

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Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

Constitutive NF-κB/Rel Activation in Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Prostate stem cell antigen is overexpressed in prostate cancer metastases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Proteasome inhibition in hematologic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Evidence that mitogen-activated protein kinase phosphatase-1 induction by proteasome inhibitors plays an antiapoptotic role

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Inhibition of NF-kappaB activity by BAY 11-7082 increases apoptosis in multidrug resistant leukemic T-cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021

Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401877

7 January 2021