Nuclear factor-kappaB: its role in health and disease (Q35791198)

10 August 2017

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title

Nuclear factor-kappaB: its role in health and disease (English)

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10 August 2017

Ashok Kumar

1

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10 August 2017

Yasunari Takada

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2

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10 August 2017

Aladin M Boriek

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3

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10 August 2017

Bharat B Aggarwal

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4

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10 August 2017

language of work or name

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3 June 2004

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Journal of Molecular Medicine

10 August 2017

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10 August 2017

82

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10 August 2017

434-448

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10 August 2017

7

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https://scigraph.springernature.com/pub.10.1007/s00109-004-0555-y

10 August 2017

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cites work

Mature T cells depend on signaling through the IKK complex.

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12 December 2020

Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice.

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12 December 2020

NF-kappaB in neuronal plasticity and neurodegenerative disorders

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12 December 2020

Sustained activation of nuclear factor kappa B and activator protein 1 in chronic heart failure

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12 December 2020

Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis

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12 December 2020

Cell specific effects of glucocorticoid treatment on the NF-kappaBp65/IkappaBalpha system in patients with Crohn's disease

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12 December 2020

Activation of mitogen-activated protein kinases and activator protein-1 in myocardial infarction in rats.

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12 December 2020

Ozone-induced IL-8 expression and transcription factor binding in respiratory epithelial cells

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12 December 2020

IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

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12 December 2020

A20 is dynamically regulated in the heart and inhibits the hypertrophic response

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12 December 2020

Nuclear factor-kappa B and cancer: its role in prevention and therapy

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12 December 2020

Induction of RANTES chemokine expression in human astrocytic cells is dependent upon activation of NF-kappaB transcription factor.

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12 December 2020

NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses

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12 December 2020

Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling

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12 December 2020

Effects of rhinovirus infection on histamine and cytokine production by cell lines from human mast cells and basophils

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12 December 2020

Particles and periimplant bone resorption

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12 December 2020

In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction

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12 December 2020

Activation of NF-kappaB by hepatitis B virus X protein through an IkappaB kinase-independent mechanism

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12 December 2020

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

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12 December 2020

Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB.

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12 December 2020

Activation of nuclear factor kappa B in Crohn's disease

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12 December 2020

Rel/NF-kappaB transcription factors: key mediators of B-cell activation

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12 December 2020

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12 December 2020

The role of nuclear factor-kappa B in pulmonary diseases

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12 December 2020

Hostile takeovers: viral appropriation of the NF-kB pathway

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12 December 2020

B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha

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12 December 2020

Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

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12 December 2020

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

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12 December 2020

Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy?

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12 December 2020

NF-kappaB signaling pathways in mammalian and insect innate immunity

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12 December 2020

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

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12 December 2020

A small molecule inhibitor of redox-regulated NF-kappa B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model

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12 December 2020

Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rat lung

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12 December 2020

Aberrant rel/nfkb genes and activity in human cancer

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12 December 2020

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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12 December 2020

Myonuclear apoptosis in dystrophic mdx muscle occurs by perforin-mediated cytotoxicity

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12 December 2020

Possible new role for NF-kappaB in the resolution of inflammation.

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12 December 2020

Signal transduction: aspirin, ubiquitin and cancer

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12 December 2020

RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells

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12 December 2020

Divergent gene regulation and growth effects by NF-κB in epithelial and mesenchymal cells of human skin

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12 December 2020

In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis

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12 December 2020

Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators

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12 December 2020

Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism

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12 December 2020

Rhinovirus infection induces expression of its own receptor intercellular adhesion molecule 1 (ICAM-1) via increased NF-kappaB-mediated transcription.

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12 December 2020

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

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12 December 2020

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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12 December 2020

Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium

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12 December 2020

Antiproliferative effects of IFN-alpha correlate with the downregulation of nuclear factor-kappa B in human Burkitt lymphoma Daudi cells

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12 December 2020

Potent and stable attenuation of live-HIV-1 by gain of a proteolysis-resistant inhibitor of NF-kappaB (IkappaB-alphaS32/36A) and the implications for vaccine development

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12 December 2020

Proteasome inhibition: a new strategy in cancer treatment

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12 December 2020

Transcription factor NF-kappaB and inhibitor I kappaBalpha are localized in macrophages in active multiple sclerosis lesions.

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12 December 2020

Effects of inhaled beta agonist and corticosteroid treatment on nuclear transcription factors in bronchial mucosa in asthma

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12 December 2020

Nuclear factor-kappaB as a therapeutic target in critical care medicine

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12 December 2020

The regulation and roles of Rel/NF-kappa B transcription factors during lymphocyte activation.

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12 December 2020

Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha

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12 December 2020

Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study

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12 December 2020

Signalling pathways of the TNF superfamily: a double-edged sword

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12 December 2020

RNA interference directed against viral and cellular targets inhibits human immunodeficiency Virus Type 1 replication

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12 December 2020

Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines

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12 December 2020

Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation

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12 December 2020

Interaction of NF-kappaB and NFAT with the interferon-gamma promoter

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12 December 2020

NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle

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12 December 2020

B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50

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12 December 2020

Induction of nuclear factor kappaB and activation protein 1 in postischemic myocardium

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12 December 2020

Activation of NF-kappaB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology.

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12 December 2020

Inhaled glucocorticoids for asthma

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12 December 2020

Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction.

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12 December 2020

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

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12 December 2020

New insights into the role of nuclear factor-kB in cell growth regulation

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12 December 2020

Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates

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12 December 2020

NF-kappa B/Rel participation in the lymphokine-dependent proliferation of T lymphoid cells

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12 December 2020

Expression of either NF-kappaB p50 or p52 in osteoclast precursors is required for IL-1-induced bone resorption

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12 December 2020

Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB.

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12 December 2020

Activation and localization of transcription factor, nuclear factor-kappaB, in asthma

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12 December 2020

Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure

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12 December 2020

NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions.

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12 December 2020

Activators and target genes of Rel/NF-kappaB transcription factors

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12 December 2020

Activated nuclear factor-kappaB is present in the coronary vasculature in experimental hypercholesterolemia

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12 December 2020

Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis

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12 December 2020

The proteasome--an emerging therapeutic target in cancer

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12 December 2020

B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching

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12 December 2020

Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-kappaB and CBF1.

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12 December 2020

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

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12 December 2020

Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase

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12 December 2020

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

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12 December 2020

Transcriptional Regulation of Type I Diabetes by NF-κB

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12 December 2020

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades

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12 December 2020

Activation of nuclear factor-kappaB is necessary for myotrophin-induced cardiac hypertrophy

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12 December 2020

NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction

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12 December 2020

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

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12 December 2020

IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells

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12 December 2020

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

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12 December 2020

NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint

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12 December 2020

Limb and skin abnormalities in mice lacking IKKalpha

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12 December 2020

Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

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12 December 2020

Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation

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12 December 2020

Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue

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12 December 2020

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

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12 December 2020

Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein

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12 December 2020

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

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12 December 2020

Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines

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12 December 2020

Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I

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12 December 2020

Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes

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12 December 2020

Antioxidants, NFkappaB activation, and diabetogenesis

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12 December 2020

Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

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12 December 2020

Structural alterations of the NF-kappa B transcription factor lyt-10 in lymphoid malignancies

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12 December 2020

Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

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12 December 2020

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

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12 December 2020

Importance of NF-kappaB in rheumatoid synovial tissues: in situ NF-kappaB expression and in vitro study using cultured synovial cells

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12 December 2020

NF-kappaB regulation in the immune system

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12 December 2020

NF-kappaB and bone: the breaking point

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12 December 2020

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

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12 December 2020

Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IκBα/NF-κB pathway in limb-girdle muscular dystrophy type 2A

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12 December 2020

Role of nuclear factor-kappa B in atherogenesis

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12 December 2020

Is NF-kappaB the sensor of oxidative stress?

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12 December 2020

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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12 December 2020

The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation

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12 December 2020

Ozone induction of cytokine-induced neutrophil chemoattractant (CINC) and nuclear factor-kappa b in rat lung: inhibition by corticosteroids.

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12 December 2020

A chronic inflammatory response dominates the skeletal muscle molecular signature in dystrophin-deficient mdx mice

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12 December 2020

NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition

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12 December 2020

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

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12 December 2020

Rel/NF-kappaB/IkappaB proteins and cancer

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12 December 2020

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

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12 December 2020

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

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12 December 2020

Nuclear translocation of NF-kappaB in cholinergic neurons of patients with Alzheimer's disease

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12 December 2020

Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice.

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12 December 2020

The IKK/NF-kappa B pathway

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12 December 2020

Correlation between nuclear factor-kappaB activity in bronchial brushing samples and lung dysfunction in an animal model of asthma

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12 December 2020

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family

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12 December 2020

Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV

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12 December 2020

Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation

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12 December 2020

Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha.

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12 December 2020

Expression of relB is required for the development of thymic medulla and dendritic cells

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12 December 2020

Mechanical stretch activates nuclear factor-kappaB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: implications in asthma

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12 December 2020

Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.

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12 December 2020

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase

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12 December 2020

Dissection of temporal gene expression signatures of affected and spared muscle groups in dystrophin-deficient (mdx) mice.

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12 December 2020

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

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12 December 2020

Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis

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12 December 2020

Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis

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12 December 2020

Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis

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12 December 2020

CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response

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12 December 2020

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

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12 December 2020

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

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12 December 2020

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

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12 December 2020

Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy

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12 December 2020

Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation.

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12 December 2020

A novel therapeutic vaccine approach, targeting RANKL, prevents bone destruction in bone-related disorders

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12 December 2020

Pathophysiology of limb girdle muscular dystrophy type 2A: hypothesis and new insights into the IkappaBalpha/NF-kappaB survival pathway in skeletal muscle.

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12 December 2020

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

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12 December 2020

Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma

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12 December 2020

NF-kappa B: a crucial transcription factor for glial and neuronal cell function

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12 December 2020

NF-kappaB: pivotal mediator or innocent bystander in atherogenesis?

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12 December 2020

NF-kappa B activation in human knee-joint synovial tissue during the early stage of joint inflammation

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12 December 2020

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

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12 December 2020

The allergen Der p1 induces NF-kappaB activation through interference with IkappaB alpha function in asthmatic bronchial epithelial cells

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12 December 2020

Nuclear transcription factor-kappaB in Hodgkin's disease

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12 December 2020

NF-kappaB at the crossroads of life and death

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12 December 2020

IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis

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12 December 2020

The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice

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12 December 2020

Requirement for NF-kappaB in osteoclast and B-cell development

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12 December 2020

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

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12 December 2020

Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis

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12 December 2020

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

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12 December 2020

Regulatory functions of ubiquitination in the immune system

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12 December 2020

Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice

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12 December 2020

Pervanadate-induced nuclear factor-kappaB activation requires tyrosine phosphorylation and degradation of IkappaBalpha. Comparison with tumor necrosis factor-alpha

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12 December 2020

NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

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12 December 2020

Activation of nuclear factor-kappaB in inflammatory myopathies and Duchenne muscular dystrophy.

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12 December 2020

Respiratory viruses and exacerbations of asthma in adults

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12 December 2020

An intact NF-kappa B signaling pathway is required for maintenance of mature B cell subsets

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12 December 2020

Respiratory epithelial cell expression of vascular cell adhesion molecule-1 and its up-regulation by rhinovirus infection via NF-kappaB and GATA transcription factors

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12 December 2020

Identification of a Role for NF- B2 in the Regulation of Apoptosis and in Maintenance of T Cell-Mediated Immunity to Toxoplasma gondii

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12 December 2020

NF-kappa B: arresting a major culprit in cancer

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12 December 2020

NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells

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12 December 2020

Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion

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12 December 2020

Simvastatin reduces NF-kappaB activity in peripheral mononuclear and in plaque cells of rabbit atheroma more markedly than lipid lowering diet

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12 December 2020

Do immune cells promote the pathology of dystrophin-deficient myopathies?

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12 December 2020

Oxidative stress and gene expression: the AP-1 and NF-kappaB connections

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12 December 2020

Inducible expression of IkappaBalpha repressor mutants interferes with NF-kappaB activity and HIV-1 replication in Jurkat T cells

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12 December 2020

Helper (CD4(+)) and cytotoxic (CD8(+)) T cells promote the pathology of dystrophin-deficient muscle

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12 December 2020

Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms

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12 December 2020

Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy.

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12 December 2020

Nuclear factor kappa-B and the heart

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12 December 2020

Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB

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12 December 2020

Transcription factors and asthma

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12 December 2020

Mechanisms of persistent NF-kappa B activity in the bronchi of an animal model of asthma

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12 December 2020

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

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12 December 2020

Incontinentia pigmenti (Bloch-Sulzberger syndrome).

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12 December 2020

Dendritic cell survival and maturation are regulated by different signaling pathways.

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12 December 2020

Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses

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12 December 2020

The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes

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12 December 2020

NF-kappaB signaling and human disease

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12 December 2020

Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure.

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12 December 2020

10.1007/S00109-004-0555-Y

Identifiers

DOI

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10 August 2017

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