Recombination-activating gene proteins: more regulation, please (Q28270922)

V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins

Europe PubMed Central

title

Recombination-activating gene proteins: more regulation, please (English)

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author name string

Moshe J Sadofsky

series ordinal

1

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language of work or name

English

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publication date

August 2004

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published in

Immunological Reviews

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volume

200

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page(s)

83-9

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cites work

1 reference

https://api.crossref.org/works/10.1111/J.0105-2896.2004.00164.X

The RAG1 N-terminal domain is an E3 ubiquitin ligase

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.0105-2896.2004.00164.X

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.0105-2896.2004.00164.X

Themes and variations on ubiquitylation

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.0105-2896.2004.00164.X

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.0105-2896.2004.00164.X

The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.0105-2896.2004.00164.X

Control of biochemical reactions through supramolecular RING domain self-assembly

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.0105-2896.2004.00164.X

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.0105-2896.2004.00164.X

Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.0105-2896.2004.00164.X

A conserved RING finger protein required for histone H2B monoubiquitination and cell size control.

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.0105-2896.2004.00164.X

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.0105-2896.2004.00164.X

Autoubiquitylation of the V(D)J recombinase protein RAG1

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.0105-2896.2004.00164.X

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

21 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism

21 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Somatic generation of antibody diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Stimulation of V(D)J cleavage by high mobility group proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

The RAG proteins in V(D)J recombination: more than just a nuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Ordered assembly of the V(D)J synaptic complex ensures accurate recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Assembly of the RAG1/RAG2 synaptic complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

V(D)J recombination: RAG proteins, repair factors, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

In vivo transposition mediated by V(D)J recombinase in human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Targeted transposition by the V(D)J recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

The C-terminal portion of RAG2 protects against transposition in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Full-length RAG-2, and Not Full-length RAG-1, Specifically Suppresses RAG-mediated Transposition but Not Hybrid Joint Formation or Disintegration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Postcleavage sequence specificity in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

The V(D)J recombination activating gene, RAG-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

A superfamily of protein tags: ubiquitin, SUMO and related modifiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

RAG2 is down-regulated by cytoplasmic sequestration and ubiquitin-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

A short peptide at the C terminus is responsible for the nuclear localization of RAG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

DNA-Rag Protein Interactions in the Control of Selective D Gene Utilization in the TCRβ Locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Cutting edge: targeting of V beta to D beta rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

The elusive structural role of ubiquitinated histones

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Degradation or maintenance: actions of the ubiquitin system on eukaryotic chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

Transcriptional regulation by histone ubiquitination and deubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X

The U box is a modified RING finger — a common domain in ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00164.X