Ordered assembly of the V(D)J synaptic complex ensures accurate recombination (Q34090070)

30 July 2017

title

Ordered assembly of the V(D)J synaptic complex ensures accurate recombination (English)

1 reference

30 July 2017

Jessica M Jones

1

1 reference

30 July 2017

Martin Gellert

series ordinal

2

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30 July 2017

publication date

1 August 2002

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30 July 2017

language of work or name

0 references

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30 July 2017

volume

21

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30 July 2017

issue

15

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30 July 2017

page(s)

4162-4171

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describes a project that uses

30 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC126141/fullTextXML

inferred from PubMed Central ID database lookup

cites work

V(D)J recombination: RAG proteins, repair factors, and regulation

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Effect of HIV integrase inhibitors on the RAG1/2 recombinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Assembly of the RAG1/RAG2 Synaptic Complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.

28 July 2018

1 reference

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Functional organization of single and paired V(D)J cleavage complexes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire

28 July 2018

1 reference

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A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1.

28 July 2018

1 reference

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Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

28 July 2018

1 reference

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RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

28 July 2018

1 reference

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Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1.

28 July 2018

1 reference

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The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Functional Analysis of Coordinated Cleavage in V(D)J Recombination

28 July 2018

1 reference

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Distinct Roles of RAG1 and RAG2 in Binding the V(D)J Recombination Signal Sequences

28 July 2018

1 reference

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Assembly of a 12/23 Paired Signal Complex: A Critical Control Point in V(D)J Recombination

28 July 2018

1 reference

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RAG-1 and RAG-2-Dependent Assembly of Functional Complexes with V(D)J Recombination Substrates in Solution

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Enhancer control of local accessibility to V(D)J recombinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Stimulation of V(D)J cleavage by high mobility group proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Defect in rearrangement of the most 5' TCR-J alpha following targeted deletion of T early alpha (TEA): implications for TCR alpha locus accessibility

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Initiation of V(D)J recombination in vitro obeying the 12/23 rule

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Characterization of broken DNA molecules associated with V(D)J recombination

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Somatic generation of antibody diversity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Host protein requirements for in vitro site-specific DNA inversion

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

The interaction of recombination proteins with supercoiled DNA: defining the role of supercoiling in lambda integrative recombination

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Synapsis of attachment sites during lambda integrative recombination involves capture of a naked DNA by a protein-DNA complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Double-strand breaks associated with V(D)J recombination at the TCR delta locus in murine thymocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Comparative architecture of transposase and integrase complexes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Initiation of V(D)J recombination in a cell-free system.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Characterization of the Interaction between the Lambda Intasome andattB

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126141

Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA

28 October 2018

1 reference

12 December 2020

V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals

1 reference

12 December 2020

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

1 reference

12 December 2020

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

1 reference

12 December 2020

A functional analysis of the Tn5 transposase. Identification of domains required for DNA binding and multimerization

1 reference

12 December 2020

Characterization of a Tn5 pre-cleavage synaptic complex

1 reference

12 December 2020

Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usage

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/CDF394

1 reference

30 July 2017

1 reference

30 July 2017

1 reference