Differential ubiquitination defines the functional status of the tumor suppressor Smad4. (Q40641509)

22 September 2017

Differential ubiquitination defines the functional status of the tumor suppressor Smad4. (English)

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22 September 2017

protein ubiquitination

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Anita Morén

1

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22 September 2017

Ulf Hellman

2

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22 September 2017

Yuri Inada

3

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22 September 2017

Takeshi Imamura

4

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22 September 2017

Carl-Henrik Heldin

5

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22 September 2017

Aristidis Moustakas

6

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22 September 2017

language of work or name

English

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publication date

5 June 2003

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Journal of Biological Chemistry

22 September 2017

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22 September 2017

278

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22 September 2017

33571-33582

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22 September 2017

35

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How cells read TGF-beta signals

22 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M300159200

Smads as transcriptional co-modulators

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M300159200

Signaling of transforming growth factor-beta family members through Smad proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M300159200

Signaling inputs converge on nuclear effectors in TGF-beta signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M300159200

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M300159200

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M300159200

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M300159200

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Structural basis of Smad1 activation by receptor kinase phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Crystal Structure of a Phosphorylated Smad2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Phosphorylation regulation of the interaction between Smad7 and activin type I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300159200

21 January 2018

Identifiers

DOI

10.1074/JBC.M300159200

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22 September 2017

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