The TLR and IL-1 signalling network at a glance (Q27013358)

Crossref

language of work or name

1 reference

1 June 2014

1 reference

published in

Journal of Cell Science

1 reference

volume

127

1 reference

issue

Pt 11

1 reference

page(s)

2383-90

1 reference

IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production

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Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

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The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN

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IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 March 2017

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Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

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Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

21 March 2017

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E2 interaction and dimerization in the crystal structure of TRAF6

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 March 2017

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Structural Basis for Recognition of Diubiquitins by NEMO

21 March 2017

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MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.

21 March 2017

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Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing

21 March 2017

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Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

21 March 2017

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Negative regulation of toll-like receptor-mediated signaling by Tollip

21 March 2017

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Oncogenically active MYD88 mutations in human lymphoma

21 March 2017

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Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

21 March 2017

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Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

21 March 2017

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Integrating cell-signalling pathways with NF-kappaB and IKK function

21 March 2017

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Intracellular trafficking of interleukin-1 receptor I requires Tollip

21 March 2017

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Regulation and function of IKK and IKK-related kinases

21 March 2017

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A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

21 March 2017

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IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9

21 March 2017

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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

21 March 2017

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IRF-7 is the master regulator of type-I interferon-dependent immune responses

21 March 2017

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The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling

21 March 2017

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Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

21 March 2017

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 March 2017

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

21 March 2017

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Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1

21 March 2017

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Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

21 March 2017

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Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08

21 March 2017

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Macrophage plasticity and polarization: in vivo veritas

21 March 2017

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IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation.

7 April 2017

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Molecular control of the NEMO family of ubiquitin-binding proteins

28 September 2017

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Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

28 September 2017

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Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling

28 September 2017

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ABIN1 dysfunction as a genetic basis for lupus nephritis

28 September 2017

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Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.

28 September 2017

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IRF-5 and NF-κB p50 co-regulate IFN-β and IL-6 expression in TLR9-stimulated human plasmacytoid dendritic cells.

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Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.

28 September 2017

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Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice

28 September 2017

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28 September 2017

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Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.

28 September 2017

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Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells.

28 September 2017

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Direct, noncatalytic mechanism of IKK inhibition by A20.

28 September 2017

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The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling

28 September 2017

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ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling

28 September 2017

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Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IκBα deficiency

28 September 2017

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New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein

28 September 2017

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Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

28 September 2017

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Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha

28 September 2017

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Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

28 September 2017

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Novel cross-talk within the IKK family controls innate immunity

28 September 2017

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Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency

28 September 2017

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TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.

28 September 2017

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Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis

28 September 2017

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Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes

28 September 2017

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TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis

28 September 2017

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An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.

28 September 2017

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Psoriasis bench to bedside: genetics meets immunology

28 September 2017

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Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.

28 September 2017

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Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

28 September 2017

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Signal processing by its coil zipper domain activates IKK gamma

28 September 2017

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Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

28 September 2017

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A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity

28 September 2017

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Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus

28 September 2017

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IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression

28 September 2017

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Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide

28 September 2017

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

28 September 2017

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Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

IkappaB kinase is an essential component of the Tpl2 signaling pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

Feedback control of the protein kinase TAK1 by SAPK2a/p38

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

Complete dependence on IRAK4 kinase activity in TLR2, but not TLR4, signaling pathways underlies decreased cytokine production and increased susceptibility to Streptococcus pneumoniae infection in IRAK4 kinase-inactive mice

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

Investigation of 20 non-HLA (human leucocyte antigen) psoriasis susceptibility loci in Chinese patients with psoriatic arthritis and psoriasis vulgaris

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

Essential function for the kinase TAK1 in innate and adaptive immune responses

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038938

Chemical approaches to angiogenesis

28 November 2018

1 reference

12 December 2020

TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population

1 reference

12 December 2020

Neutrophils Require SHP1 To Regulate IL-1 Production and Prevent Inflammatory Skin Disease

1 reference

12 December 2020

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

1 reference

12 December 2020

Identifiers

DOI

10.1242/JCS.149831

1 reference

1 reference

1 reference

PubMed publication ID

24829146

1 reference