The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (Q27860900)

Innate immune recognition

Europe PubMed Central

title

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (English)

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Taro Kawai

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Shizuo Akira

series ordinal

2

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language of work or name

English

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publication date

May 2010

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published in

Nature Immunology

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volume

11

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page(s)

373-84

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issue

5

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cites work

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Pathogen recognition and innate immunity

21 April 2017

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Innate immune recognition of viral infection

21 April 2017

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Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

21 April 2017

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

21 April 2017

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Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

21 April 2017

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Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer

21 April 2017

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CD36 is a sensor of diacylglycerides

21 April 2017

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A toll-like receptor that prevents infection by uropathogenic bacteria

21 April 2017

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Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

21 April 2017

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 April 2017

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UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

21 April 2017

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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

21 April 2017

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Herpes simplex virus encephalitis in human UNC-93B deficiency

21 April 2017

1 reference

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

21 April 2017

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Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages

21 April 2017

1 reference

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

21 April 2017

1 reference

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

21 April 2017

1 reference

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

21 April 2017

1 reference

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

21 April 2017

1 reference

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

21 April 2017

1 reference

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

21 April 2017

1 reference

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 April 2017

1 reference

Structural Basis for Recognition of Diubiquitins by NEMO

21 April 2017

1 reference

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

21 April 2017

1 reference

Regulation and function of IKK and IKK-related kinases

21 April 2017

1 reference

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

21 April 2017

1 reference

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

21 April 2017

1 reference

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway

21 April 2017

1 reference

TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation

21 April 2017

1 reference

DUBA: a deubiquitinase that regulates type I interferon production

21 April 2017

1 reference

NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

21 April 2017

1 reference

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

21 April 2017

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Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

21 April 2017

1 reference

The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis

21 April 2017

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 April 2017

1 reference

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

21 April 2017

1 reference

The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1

21 April 2017

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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

21 April 2017

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HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

21 April 2017

1 reference

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

21 April 2017

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Mutation of DNASE1 in people with systemic lupus erythematosus

21 April 2017

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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

21 April 2017

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Trex1 prevents cell-intrinsic initiation of autoimmunity

21 April 2017

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Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

21 April 2017

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Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses

21 April 2017

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Toll-like receptors: critical proteins linking innate and acquired immunity

21 April 2017

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The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

21 April 2017

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The inflammasomes: guardians of the body

21 April 2017

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Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

21 April 2017

1 reference

Autophagy-dependent viral recognition by plasmacytoid dendritic cells

21 April 2017

1 reference

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

21 April 2017

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A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

21 April 2017

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

21 April 2017

1 reference

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

21 April 2017

1 reference

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

21 April 2017

1 reference

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

21 April 2017

1 reference

TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis

21 April 2017

1 reference

12 December 2020

A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors

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12 December 2020

Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals

1 reference

12 December 2020

Intracellular DNA recognition

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12 December 2020

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

1 reference

12 December 2020

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

1 reference

12 December 2020

Toll-like receptor and RIG-I-like receptor signaling

1 reference

12 December 2020

Inflammasome recognition of influenza virus is essential for adaptive immune responses

1 reference

12 December 2020

Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.

1 reference

12 December 2020

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

1 reference

12 December 2020

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury

1 reference

12 December 2020

Yaa autoimmune phenotypes are conferred by overexpression of TLR7.

1 reference

12 December 2020

Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

1 reference

12 December 2020

Regulation of the innate immune response by threonine-phosphatase of Eyes absent

1 reference

12 December 2020

Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells

1 reference

12 December 2020

A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses

1 reference

12 December 2020

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

1 reference

12 December 2020

Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.

1 reference

12 December 2020

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

1 reference

12 December 2020

Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.

1 reference

12 December 2020

Features of systemic lupus erythematosus in Dnase1-deficient mice

1 reference

12 December 2020

Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.

1 reference

12 December 2020

TLR11 activation of dendritic cells by a protozoan profilin-like protein.

1 reference

12 December 2020

The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

1 reference

12 December 2020

The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

1 reference

12 December 2020

Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4

1 reference

12 December 2020

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

1 reference

12 December 2020

The dsRNA binding site of human Toll-like receptor 3.

1 reference

12 December 2020

Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication

1 reference

12 December 2020

Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.

1 reference

12 December 2020

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1.

1 reference

12 December 2020

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

1 reference

12 December 2020

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta

1 reference

12 December 2020

TLR accessory molecules

1 reference

12 December 2020

TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus

1 reference

12 December 2020

Targeting HMGB1 in inflammation

1 reference

12 December 2020

Ubiquitylation in innate and adaptive immunity.

1 reference

12 December 2020

Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger

1 reference

12 December 2020

Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation

1 reference

12 December 2020

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

1 reference

12 December 2020

Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.

1 reference

12 December 2020

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

1 reference

12 December 2020

The extra domain A of fibronectin activates Toll-like receptor 4.

1 reference

12 December 2020

Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.

1 reference

12 December 2020

Cathepsins are required for Toll-like receptor 9 responses

1 reference

12 December 2020

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

1 reference

12 December 2020

Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses

1 reference

12 December 2020

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

1 reference

12 December 2020

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.

1 reference

12 December 2020

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

1 reference

12 December 2020

Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells

1 reference

12 December 2020

Activation of autoreactive B cells by CpG dsDNA

1 reference

12 December 2020

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.

1 reference

12 December 2020

Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.

1 reference

12 December 2020

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

1 reference

12 December 2020

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling

1 reference

12 December 2020

Structures of the toll-like receptor family and its ligand complexes

1 reference

12 December 2020

The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages

1 reference

12 December 2020

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

1 reference

12 December 2020

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

1 reference

12 December 2020

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

1 reference

12 December 2020

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

1 reference

12 December 2020

Fen1 mutations result in autoimmunity, chronic inflammation and cancers

1 reference

12 December 2020

Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease.

1 reference

12 December 2020

The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation

1 reference

12 December 2020

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

1 reference

12 December 2020

Heat shock proteins and immune system

1 reference

12 December 2020

Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

1 reference

12 December 2020

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

1 reference

12 December 2020

TLR3 deficiency in patients with herpes simplex encephalitis

1 reference

12 December 2020

IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation.

1 reference

12 December 2020

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

1 reference

12 December 2020

Toll-like receptor 3 promotes cross-priming to virus-infected cells.

1 reference

12 December 2020

PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit

1 reference

12 December 2020

Fungal Recognition by TLR2 and Dectin-1.

1 reference

12 December 2020

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells.

1 reference

12 December 2020

Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination

1 reference

12 December 2020

RNA recognition and signal transduction by RIG-I-like receptors

1 reference

12 December 2020

Influenza virus activates inflammasomes via its intracellular M2 ion channel

1 reference

7 January 2021