A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. (Q49050925)

18 February 2018

title

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. (English)

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18 February 2018

author

Steven Staelens

13

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Manolis Pasparakis

17

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Rudi Beyaert

19

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Jonathan Maelfait

object named as

Jonathan Maelfait

3

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Patrick Matthys

object named as

Patrick Matthys

14

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Bart Lambrecht

15

object named as

Bart N Lambrecht

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18 February 2018

author name string

Mourad Matmati

1

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Peggy Jacques

2

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Eveline Verheugen

4

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Mirjam Kool

5

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Mozes Sze

6

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Lies Geboes

7

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Els Louagie

8

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Conor Mc Guire

9

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Lars Vereecke

10

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Yuanyuan Chu

11

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Louis Boon

12

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Marc Schmidt-Supprian

16

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Dirk Elewaut

18

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Geert van Loo

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language of work or name

English

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publication date

14 August 2011

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18 February 2018

published in

Nature Genetics

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volume

43

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page(s)

908-912

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issue

9

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18 February 2018

https://scigraph.springernature.com/pub.10.1038/ng.874

exact match

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cites work

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

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12 December 2020

Fecal microbiota in early rheumatoid arthritis

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12 December 2020

A20: central gatekeeper in inflammation and immunity

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Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice

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Tumor necrosis factor-alpha antagonists for the treatment of rheumatic diseases

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12 December 2020

Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis

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RANKL-RANK signaling in osteoclastogenesis and bone disease

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12 December 2020

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis

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12 December 2020

Oral antibiotics as a novel therapy for arthritis: evidence for a beneficial effect of intestinal Escherichia coli

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12 December 2020

The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals

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12 December 2020

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

1 reference

12 December 2020

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

1 reference

12 December 2020

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

1 reference

12 December 2020

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

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12 December 2020

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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12 December 2020

Rheumatoid arthritis association at 6q23.

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12 December 2020

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

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12 December 2020

Oral administration of lipopolysaccharide exacerbates collagen-induced arthritis in mice.

1 reference

12 December 2020

Freund's complete adjuvant induces arthritis in mice lacking a functional interferon-gamma receptor by triggering tumor necrosis factor alpha-driven osteoclastogenesis.

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12 December 2020

The role of toll-like receptors in rheumatoid arthritis

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12 December 2020

A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.

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12 December 2020

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

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12 December 2020

Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis

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12 December 2020

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

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12 December 2020

Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

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12 December 2020

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

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12 December 2020

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

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12 December 2020

Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1 reference

12 December 2020

Targeting Toll-like receptors: emerging therapeutics?

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12 December 2020

Cytokines in the pathogenesis of rheumatoid arthritis

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12 December 2020

Role of enteric bacteria in the pathogenesis of rheumatoid arthritis: evidence for antibodies to enterobacterial common antigens in rheumatoid sera and synovial fluids

1 reference

12 December 2020

Identifiers

DOI

10.1038/NG.874

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18 February 2018

PubMed ID

21841782

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18 February 2018