RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo (Q24539093)

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English	RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo	scientific article

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6 January 2020

retracted paper

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Retraction Watch

29 December 2023

https://doi.org/10.1074/jbc.RX120.015588

http://retractionwatch.com/?s=jasti+s+rao

RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo (English)

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6 January 2020

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prostate cancer

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based on heuristic

inferred from title

RNA interference

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based on heuristic

inferred from title

Christopher S Gondi

2

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6 January 2020

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Jasti S Rao

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Sai MuraliKrishna Pulukuri

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Sajani S Lakka

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Aman Jutla

4

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Norman Estes

5

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6 January 2020

Meena Gujrati

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26 August 2005

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6 January 2020

Journal of Biological Chemistry

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280

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6 January 2020

36529-36540

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6 January 2020

43

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6 January 2020

Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta

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24 March 2017

Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer

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24 March 2017

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor

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24 March 2017

Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator.

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27 September 2017

Urokinase signal transduction and its role in cell migration.

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27 September 2017

Effects of blocking urokinase receptor signaling by antisense oligonucleotides in a mouse model of experimental prostate cancer bone metastases.

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27 September 2017

Assembly and function of RNA silencing complexes

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27 September 2017

Stat3 dimerization regulated by reversible acetylation of a single lysine residue

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27 September 2017

Newer therapies in advanced prostate cancer

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27 September 2017

Interfering with cancer: a brief outline of advances in RNA interference in oncology

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Farnesyltransferase inhibitor SCH-66336 downregulates secretion of matrix proteinases and inhibits carcinoma cell migration.

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27 September 2017

Adoptive immunotherapy of prostate cancer bone lesions using redirected effector lymphocytes

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27 September 2017

In vitro suppression of urokinase plasminogen activator in breast cancer cells--a comparison of two antisense strategies.

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27 September 2017

RNA interference: past, present and future.

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27 September 2017

Persistent c-FLIP(L) expression is necessary and sufficient to maintain resistance to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in prostate cancer

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27 September 2017

DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling

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27 September 2017

Small interfering RNA urokinase silencing inhibits invasion and migration of human hepatocellular carcinoma cells.

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27 September 2017

Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer

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27 September 2017

Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis

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27 September 2017

Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.

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Antisense oligodeoxynucleotides for urokinase-plasminogen activator receptor have anti-invasive and anti-proliferative effects in vitro and inhibit spontaneous metastases of human melanoma in mice

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27 September 2017

RNA interference: new mechanisms for targeted treatment?

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27 September 2017

Reduced c-Met expression by an adenovirus expressing a c-Met ribozyme inhibits tumorigenic growth and lymph node metastases of PC3-LN4 prostate tumor cells in an orthotopic nude mouse model

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27 September 2017

Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy

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27 September 2017

Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis.

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27 September 2017

Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells

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27 September 2017

Effects of hepatocyte growth factor on urokinase-type plasminogen activator (uPA) and uPA receptor in DU145 prostate cancer cells

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27 September 2017

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27 September 2017

uPAR: a versatile signalling orchestrator

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27 September 2017

Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells

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27 September 2017

The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.

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27 September 2017

Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells.

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27 September 2017

Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc compl

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27 September 2017

Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility

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27 September 2017

The amino-terminal fragment of human urokinase directs a recombinant chimeric toxin to target cells: internalization is toxin mediated.

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27 September 2017

Expression and functional analysis of voltage-activated Na+ channels in human prostate cancer cell lines and their contribution to invasion in vitro.

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30 May 2018

A urokinase-derived peptide (A6) increases survival of mice bearing orthotopically grown prostate cancer and reduces lymph node metastasis

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30 May 2018

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30 May 2018

Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling

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30 May 2018

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30 May 2018

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21 January 2018

Is gene therapy the answer for prostate cancer?

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21 January 2018

The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells.

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21 January 2018

Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling

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21 January 2018

uPA/plasmin system-mediated MMP-9 activation is implicated in bronchial epithelial cell migration

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21 January 2018

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis

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21 January 2018

Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents

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21 January 2018

High-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread

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21 January 2018

RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas.

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21 January 2018

Methylation status of uPA promoter as a molecular mechanism regulating prostate cancer invasion and growth in vitro and in vivo

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21 January 2018

Development of irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator

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21 January 2018

Comparison of the Suppressive Effects of Antisense Oligonucleotides and siRNAs Directed Against the Same Targets in Mammalian Cells

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21 January 2018

Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells

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21 January 2018

Androgen-Independent Prostate Cancer Is a Heterogeneous Group of Diseases

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Gel-Based Application of siRNA to Human Epithelial Cancer Cells Induces RNAi-Dependent Apoptosis

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21 January 2018

Involvement of Urokinase and its Receptor in the Invasiveness of Human Prostatic Carcinoma Cell Lines

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of urokinase plasminogen activator, its receptor and type-1 inhibitor in malignant and benign prostate tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/16127174

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M503111200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16127174%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16127174%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16127174%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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