Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells (Q38601915)

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scientific article published on July 2003

Language	Label	Description	Also known as
English	Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells	scientific article published on July 2003

Statements

scholarly article

1 reference

Europe PubMed Central

4 September 2017

Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells (English)

1 reference

Europe PubMed Central

4 September 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

neoplastic invasiveness

1 reference

based on heuristic

inferred from title

Gregory E. Rice

5

1 reference

Europe PubMed Central

4 September 2017

author name string

N Ahmed

1

1 reference

Europe PubMed Central

4 September 2017

K Oliva

2

1 reference

Europe PubMed Central

4 September 2017

Y Wang

3

1 reference

Europe PubMed Central

4 September 2017

M Quinn

4

1 reference

Europe PubMed Central

4 September 2017

language of work or name

0 references

publication date

1 July 2003

1 reference

Europe PubMed Central

4 September 2017

British Journal of Cancer

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Europe PubMed Central

4 September 2017

89

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Europe PubMed Central

4 September 2017

2

1 reference

Europe PubMed Central

4 September 2017

374-384

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Europe PubMed Central

4 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601098

0 references

Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Urokinase-receptor/integrin complexes are functionally involved in adhesion and progression of human breast cancer in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Proteolysis, cell adhesion, chemotaxis, and invasiveness are regulated by the u-PA-u-PAR-PAI-1 system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Role of urokinase receptor and caveolin in regulation of integrin signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Cancer invasion and tissue remodeling--cooperation of protease systems and cell types.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Urokinase plasminogen activator induces smooth muscle cell migration: key role of growth factor-like domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Prevention of metastasis by inhibition of the urokinase receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Effects of urokinase receptor occupancy on plasmin generation and proteolysis of basement membrane by human tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

6 September 2017

Association between alphavbeta6 integrin expression, elevated p42/44 kDa MAPK, and plasminogen-dependent matrix degradation in ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

27 September 2017

Downregulation of the urokinase-type plasminogen activator receptor through inhibition of translation by antisense oligonucleotide suppresses invasion of human glioblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

27 September 2017

Urokinase-type plasminogen activator receptors associate with beta1 and beta3 integrins of fibrosarcoma cells: dependence on extracellular matrix components.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

27 September 2017

Regulation of integrin function by the urokinase receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

27 September 2017

Overexpression of urokinase receptor in breast cancer cells results in increased tumor invasion, growth and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

27 September 2017

Molecular interactions in cell adhesion complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

27 September 2017

Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

23 June 2018

Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

23 June 2018

The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

23 June 2018

Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

23 June 2018

Urokinase receptor and colorectal cancer survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

23 June 2018

Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

23 June 2018

Integrin alpha(v)beta(3)/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

31 August 2018

Inhibition of colon cancer metastasis by a 3'- end antisense urokinase receptor mRNA in a nude mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

31 August 2018

[Signaling pathways regulating the expression of proteases during tumor progression]

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

31 August 2018

Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

31 August 2018

Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2394266

31 August 2018

[Constitutive activation of the ERK-MAP kinase pathway in human tumors]

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urokinase/urokinase receptor and vitronectin/alpha(v)beta(3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct integrin alphavbeta6-ERK binding: implications for tumour growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Invasion of connective tissue by human carcinoma cell lines: requirement for urokinase, urokinase receptor, and interstitial collagenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

uPA/uPAR system is active in immature dendritic cells derived from CD14+CD34+ precursors and is down-regulated upon maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12865932

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/SJ.BJC.6601098

1 reference

Europe PubMed Central

4 September 2017

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24 November 2022

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mapped directly with Wikidata item

1 reference

Europe PubMed Central

4 September 2017

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Europe PubMed Central

4 September 2017

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