Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner (Q24337323)

Cell division cycle 27

1 reference

Anaphase promoting complex subunit 4

1 reference

Anaphase promoting complex subunit 5

1 reference

Anaphase promoting complex subunit 7

1 reference

protein phosphatase binding

1 reference

Fizzy and cell division cycle 20 related 1

1 reference

Phosphatase and tensin homolog

1 reference

author

Pier Paolo Pandolfi

7

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Leonardo Salmena

Leonardo Salmena

3

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Marcos Malumbres

Marcos Malumbres

6

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Min Sup Song

1

Min Sup Song

0 references

Arkaitz Carracedo

2

Arkaitz Carracedo

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Ainara Egia

5

Ainara Egia

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author name string

Su Jung Song

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

4

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language of work or name

English

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publication date

21 January 2011

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published in

Cell

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volume

144

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issue

2

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page(s)

187-99

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cites work

1 reference

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The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory

19 March 2017

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The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

19 March 2017

1 reference

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Ubiquitination regulates PTEN nuclear import and tumor suppression

19 March 2017

1 reference

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

19 March 2017

1 reference

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Mitotic regulation of the human anaphase-promoting complex by phosphorylation

19 March 2017

1 reference

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

19 March 2017

1 reference

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TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta

19 March 2017

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The SCF ubiquitin ligase: insights into a molecular machine

19 March 2017

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PTEN: one gene, many syndromes

19 March 2017

1 reference

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Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

19 March 2017

1 reference

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

19 March 2017

1 reference

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Pten is essential for embryonic development and tumour suppression

19 March 2017

1 reference

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

19 March 2017

1 reference

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

19 March 2017

1 reference

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The anaphase promoting complex/cyclosome: a machine designed to destroy

19 March 2017

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A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

7 April 2017

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The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions

27 September 2017

1 reference

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The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression

27 September 2017

1 reference

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Differential p53-independent outcomes of p19(Arf) loss in oncogenesis

27 September 2017

1 reference

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The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

27 September 2017

1 reference

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Tenets of PTEN tumor suppression

27 September 2017

1 reference

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Polo and Aurora kinases: lessons derived from chemical biology

27 September 2017

1 reference

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The nuclear affairs of PTEN.

27 September 2017

1 reference

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Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair

27 September 2017

1 reference

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Finishing mitosis, one step at a time.

27 September 2017

1 reference

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PTEN, more than the AKT pathway

27 September 2017

1 reference

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BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

27 September 2017

1 reference

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A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

27 September 2017

1 reference

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Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

27 September 2017

1 reference

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Mitosis: a matter of getting rid of the right protein at the right time

27 September 2017

1 reference

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PTEN: a novel anti-oncogenic function independent of phosphatase activity

27 September 2017

1 reference

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PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity

27 September 2017

1 reference

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Aurora kinases link chromosome segregation and cell division to cancer susceptibility

27 September 2017

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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

27 September 2017

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Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts

27 September 2017

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PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers

27 September 2017

1 reference

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Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells

27 September 2017

1 reference

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Overexpression of murine fizzy-related (fzr) increases natural killer cell-mediated cell death and suppresses tumor growth

27 September 2017

1 reference

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Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

27 September 2017

1 reference

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Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

27 September 2017

1 reference

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Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN

27 September 2017

1 reference

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Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.

27 September 2017

1 reference

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Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation

30 May 2018

1 reference

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Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

30 May 2018

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A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

29 November 2018

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Targeting polo-like kinase 1 for cancer therapy.

29 November 2018

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Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma

29 November 2018

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Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity

29 November 2018

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Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor.

29 November 2018

1 reference

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The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells.

29 November 2018

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Frequent inactivation of PTEN/MMAC1 in primary prostate cancer

29 November 2018

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Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cells

29 November 2018

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12 December 2020

Two prostate carcinoma cell lines demonstrate abnormalities in tumor suppressor genes

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12 December 2020

Analysis of PTEN and the 10q23 region in primary prostate carcinomas

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12 December 2020

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1

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12 December 2020

p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a

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Crossref

https://api.crossref.org/works/10.1016%2FJ.CELL.2010.12.020

7 January 2021

inferred from DOI database lookup

The Ink4/Arf locus is a barrier for iPS cell reprogramming

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Crossref

https://api.crossref.org/works/10.1016%2FJ.CELL.2010.12.020

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.CELL.2010.12.020

1 reference

1524669

1524669

1 reference

1 reference

1 reference