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Cell division cycle 27 (Q21130874)

From Wikidata
mammalian protein found in Homo sapiens
  • APC3
  • cell division cycle 27 homolog
  • H-NUC
  • CDC27Hs
  • anaphase promoting complex subunit 3
  • anaphase-promoting complex, protein 3
  • CDC27 homolog
  • nuc2 homolog
  • D0S1430E, D17S978E
  • Anaphase-promoting complex subunit 3
  • CDC27
  • cell division cycle protein 27 homolog
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    English
    Cell division cycle 27
    mammalian protein found in Homo sapiens
    • APC3
    • cell division cycle 27 homolog
    • H-NUC
    • CDC27Hs
    • anaphase promoting complex subunit 3
    • anaphase-promoting complex, protein 3
    • CDC27 homolog
    • nuc2 homolog
    • D0S1430E, D17S978E
    • Anaphase-promoting complex subunit 3
    • CDC27
    • cell division cycle protein 27 homolog

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    23 references
    retrieved
    8 April 2019
    stated in
    Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
    GOA
    curator
    UniProt
    UniProt protein ID
    P30260
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex
    GOA
    curator
    UniProt
    UniProt protein ID
    P30260
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human interactome in three quantitative dimensions organized by stoichiometries and abundances
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Systematic analysis of human protein complexes identifies chromosome segregation proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Atomic structure of the APC/C and its mechanism of protein ubiquitination
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PP2A delays APC/C-dependent degradation of separase-associated but not free securin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
    determination method or standard
    IPI
    cell component
    biological process

    Identifiers

    RefSeq protein ID
     
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