Phosphatase and tensin homolog (Q416356)

From Wikidata
Jump to navigation Jump to search
tumor suppressor gene
  • mutated in multiple advanced cancers 1
  • PTENepsilon
  • mitochondrial phosphatase and tensin protein alpha
  • MMAC1 phosphatase and tensin homolog deleted on chromosome 10
  • phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  • PTEN
  • protein tyrosine phosphatase
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  • mitochondrial PTENalpha
  • phosphatase and tensin-like protein
edit
Language Label Description Also known as
English
Phosphatase and tensin homolog
tumor suppressor gene
  • mutated in multiple advanced cancers 1
  • PTENepsilon
  • mitochondrial phosphatase and tensin protein alpha
  • MMAC1 phosphatase and tensin homolog deleted on chromosome 10
  • phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  • PTEN
  • protein tyrosine phosphatase
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  • mitochondrial PTENalpha
  • phosphatase and tensin-like protein

Statements

molecular function
protein binding
determination method
IPI
19 references
retrieved
8 April 2019
stated in
Rak functions as a tumor suppressor by regulating PTEN protein stability and function
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
Rak functions as a tumor suppressor by regulating PTEN protein stability and function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
PTEN inhibits BMI1 function independently of its phosphatase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
retrieved
8 April 2019
stated in
Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IPI
cell component
cytoplasm
determination method
IDA
TAS
IEA
8 references
retrieved
8 April 2019
stated in
A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IEA
retrieved
8 April 2019
stated in
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IDA
retrieved
8 April 2019
stated in
NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IDA
retrieved
8 April 2019
stated in
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IDA
retrieved
8 April 2019
stated in
Subcellular localization of intracellular protein tyrosine phosphatases in T cells
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IDA
retrieved
8 April 2019
stated in
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IDA
biological process
phosphatidylinositol dephosphorylation
determination method
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IMP
retrieved
8 April 2019
stated in
A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IEA
retrieved
8 April 2019
stated in
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IDA
retrieved
8 April 2019
stated in
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IDA
negative regulation of protein kinase B signaling
determination method
IEA
IMP
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
TAS
retrieved
8 April 2019
stated in
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
GOA
curator
UniProt
UniProt protein ID
P60484
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IMP
retrieved
8 April 2019
stated in
Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IMP
retrieved
8 April 2019
stated in
TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IMP
retrieved
8 April 2019
stated in
miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IMP
retrieved
8 April 2019
stated in
Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
determination method
IEA

Identifiers

 
edit
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q416356&oldid=2086206814"