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Phosphatase and tensin homolog (Q416356)

From Wikidata
tumor suppressor gene
  • mutated in multiple advanced cancers 1
  • PTENepsilon
  • mitochondrial phosphatase and tensin protein alpha
  • MMAC1 phosphatase and tensin homolog deleted on chromosome 10
  • phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  • PTEN
  • protein tyrosine phosphatase
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  • mitochondrial PTENalpha
  • phosphatase and tensin-like protein
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    English
    Phosphatase and tensin homolog
    tumor suppressor gene
    • mutated in multiple advanced cancers 1
    • PTENepsilon
    • mitochondrial phosphatase and tensin protein alpha
    • MMAC1 phosphatase and tensin homolog deleted on chromosome 10
    • phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    • PTEN
    • protein tyrosine phosphatase
    • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    • mitochondrial PTENalpha
    • phosphatase and tensin-like protein

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    19 references
    retrieved
    8 April 2019
    stated in
    Rak functions as a tumor suppressor by regulating PTEN protein stability and function
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Rak functions as a tumor suppressor by regulating PTEN protein stability and function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PTEN inhibits BMI1 function independently of its phosphatase activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IPI
    cell component
    cytoplasm
    determination method or standard
    IDA
    TAS
    IEA
    8 references
    retrieved
    8 April 2019
    stated in
    A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Subcellular localization of intracellular protein tyrosine phosphatases in T cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IDA
    biological process
    phosphatidylinositol dephosphorylation
    determination method or standard
    IDA
    IEA
    IMP
    6 references
    retrieved
    8 April 2019
    stated in
    A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes
    GOA
    curator
    Community Assessment of Community Annotation with Ontologies
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    The lipid phosphatase activity of PTEN is critical for its tumor supressor function
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IDA
    negative regulation of protein kinase B signaling
    determination method or standard
    IEA
    IMP
    TAS
    7 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    TAS
    retrieved
    8 April 2019
    stated in
    Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
    GOA
    curator
    UniProt
    UniProt protein ID
    P60484
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    TGFβ-Stimulated MicroRNA-21 Utilizes PTEN to Orchestrate AKT/mTORC1 Signaling for Mesangial Cell Hypertrophy and Matrix Expansion
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484
    determination method or standard
    IEA
    Commons category
    PTEN phosphohydrolase
    0 references

    Identifiers

     
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