Targeting polo-like kinase 1 for cancer therapy (Q53348000)

13 May 2018

title

Targeting polo-like kinase 1 for cancer therapy (English)

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13 May 2018

author name string

Klaus Strebhardt

series ordinal

1

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13 May 2018

Axel Ullrich

series ordinal

2

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13 May 2018

publication date

1 April 2006

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13 May 2018

language of work or name

English

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published in

Nature Reviews Cancer

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13 May 2018

volume

6

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13 May 2018

issue

4

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13 May 2018

page(s)

321-330

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13 May 2018

publication type of scholarly work

review article

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A conserved mitotic kinase active at late anaphase-telophase in syncytial Drosophila embryos

cites work

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Polo-like kinases: a team that plays throughout mitosis

31 March 2020

1 reference

Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila

31 March 2020

1 reference

Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase

31 March 2020

1 reference

Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors

31 March 2020

1 reference

Identification of an early-growth-response gene encoding a novel putative protein kinase

31 March 2020

1 reference

Human Prk Is a Conserved Protein Serine/Threonine Kinase Involved in Regulating M Phase Functions

31 March 2020

1 reference

Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages

31 March 2020

1 reference

Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation

31 March 2020

1 reference

On the Regulation and Function of Human Polo-like Kinase 1 (PLK1): Effects of Overexpression on Cell Cycle Progression

31 March 2020

1 reference

Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase

31 March 2020

1 reference

Polo-like kinases and oncogenesis

31 March 2020

1 reference

Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases

31 March 2020

1 reference

The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore

31 March 2020

1 reference

Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

31 March 2020

1 reference

ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

31 March 2020

1 reference

Polo-like kinases and the orchestration of cell division

31 March 2020

1 reference

Regulation of cell cycle checkpoints by polo-like kinases

31 March 2020

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Getting in and out of mitosis with Polo-like kinase-1.

31 March 2020

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Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function

31 March 2020

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Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1

31 March 2020

1 reference

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5

31 March 2020

1 reference

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

31 March 2020

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GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes

31 March 2020

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Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation.

31 March 2020

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Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures

31 March 2020

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Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA.

31 March 2020

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Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

31 March 2020

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Functional studies on the role of the C-terminal domain of mammalian polo-like kinase

31 March 2020

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Polo-like kinase-1 is a target of the DNA damage checkpoint

31 March 2020

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Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells

31 March 2020

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Restarting the cell cycle when the checkpoint comes to a halt

31 March 2020

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Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation

31 March 2020

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

31 March 2020

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Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

31 March 2020

1 reference

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

31 March 2020

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Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

31 March 2020

1 reference

Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography

31 March 2020

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Crystal structure of aurora-2, an oncogenic serine/threonine kinase

31 March 2020

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Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

31 March 2020

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Structure and function of Polo-like kinases

31 March 2020

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Polo-like Kinase Is a Cell Cycle-regulated Kinase Activated during Mitosis

31 March 2020

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Hot lips and phosphorylation of protein kinases

31 March 2020

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Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

31 March 2020

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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

31 March 2020

1 reference

Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells

31 March 2020

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Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue

31 March 2020

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Cell cycle-regulated phosphorylation of the Xenopus polo-like kinase Plx1.

31 March 2020

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The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

31 March 2020

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The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

31 March 2020

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Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries

31 March 2020

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Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates

31 March 2020

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Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk

31 March 2020

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Assembly of Cell Regulatory Systems Through Protein Interaction Domains

31 March 2020

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Peripheral Golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and Cdc2

31 March 2020

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Plk phosphorylation regulates the microtubule-stabilizing protein TCTP.

31 March 2020

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Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling.

31 March 2020

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The polo-box-dependent induction of ectopic septal structures by a mammalian polo kinase, plk, in Saccharomyces cerevisiae

31 March 2020

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A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells

31 March 2020

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Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer

31 March 2020

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PLK (polo-like kinase), a new prognostic marker for oropharyngeal carcinomas

31 March 2020

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Prognostic value of pololike kinase expression in melanomas

31 March 2020

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Expression of polo-like kinase (PLK1) in thin melanomas: a novel marker of metastatic disease

31 March 2020

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Polo‐like kinase 1 (PLK1) is overexpressed in primary colorectal cancers

31 March 2020

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Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer

31 March 2020

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Polo-like kinase 1 expression is a prognostic factor in human colon cancer

31 March 2020

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Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas

31 March 2020

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Identification of high risk breast-cancer patients by gene expression profiling

31 March 2020

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Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines

31 March 2020

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polo encodes a protein kinase homolog required for mitosis in Drosophila

31 March 2020

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Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

31 March 2020

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Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

31 March 2020

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Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles

31 March 2020

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Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells

31 March 2020

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Silencing of polo-like kinase (Plk) 1 via siRNA causes induction of apoptosis and impairment of mitosis machinery in human prostate cancer cells: implications for the treatment of prostate cancer.

31 March 2020

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Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer.

31 March 2020

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Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.

31 March 2020

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Expression profiling reveals off-target gene regulation by RNAi

31 March 2020

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Strategies to overcome resistance to targeted protein kinase inhibitors

31 March 2020

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Smart drugs: tyrosine kinase inhibitors in cancer therapy

31 March 2020

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Progress in the discovery of polo-like kinase inhibitors.

31 March 2020

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The development and application of methods for activity-based protein profiling

31 March 2020

1 reference

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

31 March 2020

1 reference

Aurora-kinase inhibitors as anticancer agents

31 March 2020

1 reference

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

31 March 2020

1 reference

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

31 March 2020

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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

31 March 2020

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Roles of polo-like kinase 1 in the assembly of functional mitotic spindles

31 March 2020

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Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation

31 March 2020

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31 March 2020

Recycling the Cell Cycle

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Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

31 March 2020

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Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1.

31 March 2020

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Active cyclin B1-Cdk1 first appears on centrosomes in prophase

31 March 2020

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Activated Polo-Like Kinase Plx1 Is Required at Multiple Points during Mitosis in Xenopus laevis

31 March 2020

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Plk1 promotes nuclear translocation of human Cdc25C during prophase

31 March 2020

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Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells

31 March 2020

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The anaphase-promoting complex: a key factor in the regulation of cell cycle

31 March 2020

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Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

31 March 2020

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Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1

31 March 2020

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Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores

31 March 2020

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Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1

31 March 2020

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Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

31 March 2020

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A role for Plk1 phosphorylation of NudC in cytokinesis

31 March 2020

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Polo-like kinase: a novel marker of proliferation: correlation with estrogen-receptor expression in human breast cancer

31 March 2020

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Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications

31 March 2020

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Expression of polo-like kinase in ovarian cancer is associated with histological grade and clinical stage

31 March 2020

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Polo-like kinase (PLK) expression in endometrial carcinoma

31 March 2020

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Increased human polo-like kinase-1 expression in gliomas

31 March 2020

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Polo-like kinase 1 overexpression is an early event in the progression of papillary carcinoma

31 March 2020

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Overexpression of Polo-like kinase 1 is a common and early event in pancreatic cancer

31 March 2020

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Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades

31 March 2020

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Expression of Polo-Like Kinase (PLK1) in non-Hodgkin's lymphomas

31 March 2020

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Chemistry and biology of wortmannin

31 March 2020

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Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop

31 March 2020

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inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRC1841

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13 May 2018

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13 May 2018