CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms (Q24302257)

COMMD3-BMI1 readthrough

1 reference

Cyclin D1

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Cyclin dependent kinase inhibitor 1A

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Cyclin dependent kinase 6

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negative regulation of cellular senescence

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author name string

Margarida Ruas

1

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Fiona Gregory

2

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Rebecca Jones

3

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Robert Poolman

4

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Maria Starborg

5

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Janice Rowe

6

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Sharon Brookes

7

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Gordon Peters

Molecular and Cellular Biology

8

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language of work or name

English

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publication date

June 2007

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published in

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volume

27

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issue

12

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page(s)

4273-82

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cites work

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The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis

27 September 2017

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

27 September 2017

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Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

27 September 2017

1 reference

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Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes

27 September 2017

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Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors

27 September 2017

1 reference

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Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes

27 September 2017

1 reference

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Requirement of cyclin E-Cdk2 inhibition in p16(INK4a)-mediated growth suppression

27 September 2017

1 reference

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Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

27 September 2017

1 reference

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Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900050

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900050

Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900050

Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product

27 September 2017

1 reference

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Defining the molecular mechanisms of human cell immortalization

27 September 2017

1 reference

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Telomere loss: mitotic clock or genetic time bomb?

27 September 2017

1 reference

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CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900050

Cell cycle control: a complex issue

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900050

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900050

Proliferation of cancer cells despite CDK2 inhibition.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900050

Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900050

Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk4 fusion gene.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900050

Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900050

Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900050

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1900050

Differential CDK-inhibitor gene expression in aging human diploid fibroblasts

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17420273

12 December 2020

inferred from PubMed ID database lookup

S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17420273

12 December 2020

inferred from PubMed ID database lookup

Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence: roles of p16, p21, and cyclin D1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17420273

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1128/MCB.02286-06

0 references

Fatcat ID

release_zr25vrzysfdh5cu5274pjc5yje

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zr25vrzysfdh5cu5274pjc5yje

24 November 2022