Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. (Q34078091)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11726500%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

title

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors (English)

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4 December 2019

1

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4 December 2019

author name string

P Dubus

2

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4 December 2019

J Martín

3

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4 December 2019

E de la Cueva

4

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4 December 2019

S Ortega

5

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4 December 2019

M Malumbres

6

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4 December 2019

M Barbacid

7

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4 December 2019

language of work or name

English

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publication date

1 December 2001

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4 December 2019

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4 December 2019

volume

20

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4 December 2019

page(s)

6637-6647

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4 December 2019

issue

23

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Invasive melanoma in Cdk4-targeted mice

4 December 2019

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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INK4d-deficient mice are fertile despite testicular atrophy

5 July 2018

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The INK4 family of cell cycle inhibitors in cancer

5 July 2018

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Developmental defects and tumor predisposition in Rb mutant mice

5 July 2018

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Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

5 July 2018

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Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

5 July 2018

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The cell cycle and drug discovery: the promise and the hope

5 July 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

5 July 2018

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p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.

5 July 2018

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

5 July 2018

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Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

5 July 2018

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RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice

5 July 2018

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The INK4A/ARF locus and its two gene products

5 July 2018

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Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas

5 July 2018

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Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation

5 July 2018

1 reference

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CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

5 July 2018

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Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression

5 July 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

5 July 2018

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Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

5 July 2018

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

5 July 2018

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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

5 July 2018

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

5 July 2018

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Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

5 July 2018

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Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas

5 July 2018

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Tumor spectrum analysis in p53-mutant mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

The D-type cyclins and their role in tumorigenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

Principles of CDK regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

Role of the cyclin-dependent kinase inhibitors in the development of cancer.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

Effects of an Rb mutation in the mouse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

28 October 2018

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Characterization of the murine p19(ARF) promoter CpG island and its methylation pattern in primary lymphomas.

28 October 2018

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The p16INK4a/CDKN2A tumor suppressor and its relatives.

28 October 2018

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Differential expression of cyclin-dependent kinase 6 in cortical thymocytes and T-cell lymphoblastic lymphoma/leukemia.

28 October 2018

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Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

Role of the INK4a locus in tumor suppression and cell mortality.

28 October 2018

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CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

28 October 2018

1 reference

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Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=125323

Cooperative tumorigenic effects of germline mutations in Rb and p53

28 October 2018

1 reference

12 December 2020

Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance

1 reference

12 December 2020

CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons

1 reference

12 December 2020

CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines

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12 December 2020

Identifiers

DOI

10.1093/EMBOJ/20.23.6637

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11726500%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11726500%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference