Cyclin dependent kinase inhibitor 1A (Q423686)

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mammalian protein found in Homo sapiens
  • wild-type p53-activated fragment 1
  • Melanoma differentiation-associated protein 6
  • DNA synthesis inhibitor
  • p21
  • CDKN1A
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1)
  • cyclin-dependent kinase inhibitor 1
  • CDK-interaction protein 1
  • MDA-6
  • CDK-interacting protein 1
  • melanoma differentiation associated protein 6
  • CDKN1A protein, human
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Language Label Description Also known as
English
Cyclin dependent kinase inhibitor 1A
mammalian protein found in Homo sapiens
  • wild-type p53-activated fragment 1
  • Melanoma differentiation-associated protein 6
  • DNA synthesis inhibitor
  • p21
  • CDKN1A
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1)
  • cyclin-dependent kinase inhibitor 1
  • CDK-interaction protein 1
  • MDA-6
  • CDK-interacting protein 1
  • melanoma differentiation associated protein 6
  • CDKN1A protein, human

Statements

molecular function
protein binding
determination method
IPI
31 references
retrieved
10 September 2018
stated in
A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation
GOA
curator
UniProt
UniProt protein ID
P38936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
GOA
curator
UniProt
UniProt protein ID
P38936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Self-assembling protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Functional roles of p12, the fourth subunit of human DNA polymerase delta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Cyclin-binding motifs are essential for the function of p21CIP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Complex formation between hepatitis C virus core protein and p21Waf1/Cip1/Sdi1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Functional characterization of human PFTK1 as a cyclin-dependent kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
New functional activities for the p21 family of CDK inhibitors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
retrieved
10 September 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IPI
cell component
biological process
negative regulation of cell population proliferation
determination method
IDA
IEA
IMP
5 references
retrieved
5 June 2018
stated in
HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IMP
retrieved
5 June 2018
stated in
The cyclin-dependent kinase inhibitors p15INK4B and p21CIP1 are critical regulators of fibrillar collagen-induced tumor cell cycle arrest
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IMP
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IEA
retrieved
5 June 2018
stated in
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IDA
retrieved
5 June 2018
stated in
Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IDA
negative regulation of cell population proliferation
determination method
IDA
IMP
4 references
retrieved
10 September 2018
stated in
HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IMP
retrieved
10 September 2018
stated in
The cyclin-dependent kinase inhibitors p15INK4B and p21CIP1 are critical regulators of fibrillar collagen-induced tumor cell cycle arrest
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IMP
retrieved
10 September 2018
stated in
Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IDA
retrieved
10 September 2018
stated in
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P38936&geneProductId=UniProtKB:P38936
determination method
IDA

Identifiers

MeSH descriptor ID
C493956
subject named as
CDKN1A protein, human
0 references
 
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