Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a) (Q24293520)

ATM serine/threonine kinase

1 reference

RAD17 checkpoint clamp loader component

1 reference

Checkpoint kinase 1

1 reference

ATR serine/threonine kinase

1 reference

Checkpoint kinase 2

1 reference

MRE11 homolog, double strand break repair nuclease

1 reference

H2A.X variant histone

1 reference

Cyclin dependent kinase inhibitor 1A

1 reference

tumor protein p53

1 reference

cyclin dependent kinase inhibitor 2A

1 reference

replicative senescence

1 reference

5

John M Sedivy

0 references

author name string

Utz Herbig

1

0 references

Wendy A Jobling

2

0 references

Benjamin P C Chen

3

0 references

David J Chen

Extensive allelic variation and ultrashort telomeres in senescent human cells.

4

0 references

language of work or name

English

0 references

publication date

21 May 2004

0 references

published in

Molecular Cell

0 references

volume

14

0 references

page(s)

501-13

0 references

issue

4

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Reversal of human cellular senescence: roles of the p53 and p16 pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Cancer and ageing: rival demons?

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

A DNA damage checkpoint response in telomere-initiated senescence

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Protection of mammalian telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

DNA damage-induced cell-cycle phase regulation of p53 and p21waf1 in normal and ATM-defective cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Immortalisation and transformation revisited

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Polycomb CBX7 has a unifying role in cellular lifespan

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Protein kinase inhibitor 2-aminopurine overrides multiple genotoxic stress-induced cellular pathways to promote cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Short telomeres induce a DNA damage response in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Sensing and repairing DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Cytoplasmic retention of p-Erk1/2 and nuclear accumulation of actin proteins during cellular senescence in human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

DNA polymerase stalling, sister chromatid recombination and the BRCA genes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Different telomere damage signaling pathways in human and mouse cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Erosion of the telomeric single-strand overhang at replicative senescence

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

DNA damage foci at dysfunctional telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2804%2900256-4

7 January 2021

10.1016/S1097-2765(04)00256-4

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

780366

780366

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference