Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a) (Q24293520)

ATM serine/threonine kinase

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RAD17 checkpoint clamp loader component

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Checkpoint kinase 1

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ATR serine/threonine kinase

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checkpoint kinase 2

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MRE11 homolog, double strand break repair nuclease

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H2A.X variant histone

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Cyclin dependent kinase inhibitor 1A

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tumor protein p53

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cyclin dependent kinase inhibitor 2A

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replicative senescence

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5

John M Sedivy

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author name string

Utz Herbig

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Wendy A Jobling

2

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Benjamin P C Chen

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David J Chen

Extensive allelic variation and ultrashort telomeres in senescent human cells

4

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publication date

21 May 2004

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language of work or name

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14

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issue

4

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page(s)

501-13

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cites work

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Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts.

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

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Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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Cancer and ageing: rival demons?

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Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells

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A DNA damage checkpoint response in telomere-initiated senescence

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Protection of mammalian telomeres

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DNA damage-induced cell-cycle phase regulation of p53 and p21waf1 in normal and ATM-defective cells

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Immortalisation and transformation revisited

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Polycomb CBX7 has a unifying role in cellular lifespan

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Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence

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7 January 2021

Protein kinase inhibitor 2-aminopurine overrides multiple genotoxic stress-induced cellular pathways to promote cell survival

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7 January 2021

Short telomeres induce a DNA damage response in Saccharomyces cerevisiae

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Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

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Sensing and repairing DNA double-strand breaks

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Cytoplasmic retention of p-Erk1/2 and nuclear accumulation of actin proteins during cellular senescence in human diploid fibroblasts

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Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

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Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts

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Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

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JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression

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DNA polymerase stalling, sister chromatid recombination and the BRCA genes

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Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

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Different telomere damage signaling pathways in human and mouse cells

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DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

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Erosion of the telomeric single-strand overhang at replicative senescence

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DNA damage foci at dysfunctional telomeres

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Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia

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ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

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An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells

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Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage

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7 January 2021

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts

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7 January 2021

Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.

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7 January 2021

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

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7 January 2021

10.1016/S1097-2765(04)00256-4

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

15149599

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Consolidated OpenCitations Corpus – April 2017