LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity (Q29615144)

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29 December 2019

title

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity (English)

2 references

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30 April 2017

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Axel Knebel

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Mahaboobi Jaleel

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R Jeremy Nichols

2

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Maria Deak

series ordinal

3

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David G Campbell

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4

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Frank Gillardon

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5

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language of work or name

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30 April 2017

publication date

1 July 2007

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29 December 2019

2 references

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30 April 2017

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29 December 2019

volume

405

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29 December 2019

page(s)

307-317

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29 December 2019

issue

2

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30 April 2017

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

29 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

30 April 2017

1 reference

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

30 April 2017

1 reference

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LRRK2 in Parkinson's disease: protein domains and functional insights

30 April 2017

1 reference

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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

30 April 2017

1 reference

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

30 April 2017

1 reference

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Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin

30 April 2017

1 reference

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

30 April 2017

1 reference

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

30 April 2017

1 reference

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The protein kinase complement of the human genome

30 April 2017

1 reference

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ERM proteins and merlin: integrators at the cell cortex

30 April 2017

1 reference

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High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Identification of protein phosphorylation sites by a combination of mass spectrometry and solid phase Edman sequencing

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Emerging roles of pseudokinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

LRRK2: a common pathway for parkinsonism, pathogenesis and prevention?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

KESTREL: a powerful method for identifying the physiological substrates of protein kinases

3 June 2018

1 reference

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Small is beautiful: what flies tell us about ERM protein function in development

3 June 2018

1 reference

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Roc, a Ras/GTPase domain in complex proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Identification of four candidate cGMP targets in Dictyostelium

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin. Regulation by conformational change

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes

3 June 2018

1 reference

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A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations

3 June 2018

1 reference

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LRRK2 mutations in Parkinson disease

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Searching for biomarkers of Aurora-A kinase activity: identification of in vitro substrates through a modified KESTREL approach.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904520

Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures

26 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/17447891

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Parkinson disease gene LRRK2: evolutionary and structural insights

1 reference

https://pubmed.ncbi.nlm.nih.gov/17447891

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

3 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17447891

30 April 2017

Consolidated OpenCitations Corpus – April 2017

1364121

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29 December 2019

1364121

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17447891

2 references

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17447891%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

3 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17447891

30 April 2017

Consolidated OpenCitations Corpus – April 2017

1364121