GTPase activity plays a key role in the pathobiology of LRRK2. (Q33553458)

28 July 2017

GTPase activity plays a key role in the pathobiology of LRRK2. (English)

1 reference

28 July 2017

Valina L Dawson

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Ted M. Dawson

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object named as

Ted M Dawson

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28 July 2017

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Aaron D Gitler

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28 July 2017

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Darren J Moore

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28 July 2017

Yulan Xiong

1

1 reference

28 July 2017

Candice E Coombes

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28 July 2017

Austin Kilaru

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28 July 2017

Xiaojie Li

4

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28 July 2017

William J Bowers

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28 July 2017

8 April 2010

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28 July 2017

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28 July 2017

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28 July 2017

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28 July 2017

e1000902

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Creative Commons Attribution 4.0 International

28 July 2017

start time

8 April 2010

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April 2022 Public Data File from Crossref

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cites work

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Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

21 June 2018

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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

21 June 2018

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

21 June 2018

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The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

21 June 2018

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LRRK2 regulates synaptic vesicle endocytosis

21 June 2018

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21 June 2018

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The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

21 June 2018

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A Drosophila model for LRRK2-linked parkinsonism

21 June 2018

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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

21 June 2018

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

21 June 2018

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The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

21 June 2018

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The roles of kinases in familial Parkinson's disease.

21 June 2018

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LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease

21 June 2018

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Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.

21 June 2018

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The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

21 June 2018

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Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

21 June 2018

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

21 June 2018

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The R1441C mutation of LRRK2 disrupts GTP hydrolysis

21 June 2018

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Leucine-rich repeat kinase 2 associates with lipid rafts

21 June 2018

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GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

21 June 2018

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

21 June 2018

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Localization of LRRK2 to membranous and vesicular structures in mammalian brain

21 June 2018

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 June 2018

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IQGAP and mitotic exit network (MEN) proteins are required for cytokinesis and re-polarization of the actin cytoskeleton in the budding yeast, Saccharomyces cerevisiae

21 June 2018

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

21 June 2018

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Diagnosis and treatment of Parkinson disease: molecules to medicine

21 June 2018

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21 June 2018

PARK8 LRRK2 parkinsonism

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 June 2018

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

21 June 2018

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LRRK2 in Parkinson's disease: protein domains and functional insights

21 June 2018

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21 June 2018

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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

21 June 2018

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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

21 June 2018

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 June 2018

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Molecular pathophysiology of Parkinson's disease

21 June 2018

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Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

21 June 2018

1 reference

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A common LRRK2 mutation in idiopathic Parkinson's disease

21 June 2018

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 June 2018

1 reference

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851569

The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: A member of the DJ-1/ThiJ/PfpI superfamily

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851569

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851569

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

21 June 2018

1 reference

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Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851569

Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

21 June 2018

1 reference

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Systematic genetic analysis with ordered arrays of yeast deletion mutants

21 June 2018

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HSV vector-mediated gene delivery to the central nervous system

21 June 2018

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Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

21 June 2018

1 reference

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Parkinson's disease. Second of two parts

21 June 2018

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Parkinson's disease. First of two parts

21 June 2018

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 June 2018

1 reference

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Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant

21 June 2018

1 reference

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Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression

21 June 2018

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A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae

21 June 2018

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Test for LRRK2 mutations in patients with Parkinson's disease.

21 June 2018

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Lrrk2 and Lewy body disease

21 January 2018

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Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000902

Yeast cells provide insight into alpha-synuclein biology and pathobiology

21 January 2018

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Role of alpha-synuclein carboxy-terminus on fibril formation in vitro.

21 January 2018

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LRRK2 expression in normal and pathologic human brain and in human cell lines

21 January 2018

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LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins

21 January 2018

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Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.

21 January 2018

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Synthetic genetic array analysis in Saccharomyces cerevisiae.

21 January 2018

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A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20386743

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1000902

1 reference

28 July 2017

1 reference

28 July 2017

1 reference