Wikidata:Property proposal/negative diagnostic predictor
negative diagnostic predictor[edit]
Originally proposed at Wikidata:Property proposal/Natural science
| Description | the presence of the genetic variant helps to diagnose the absence of disease, used as exclusion criteria |
|---|---|
| Data type | Item |
| Domain | sequence variant (Q15304597) |
| Example | KIT M541L (Q27828219) → chronic myeloid leukemia (Q729735) |
| Source | CIViC, ClinVar |
| Planned use | To enrich wikidata with facts on sequence variants from CIViC, ClinVar and other variant resources |
| Robot and gadget jobs | ProteinBoxBot will update wikidata from authoritative resources on sequence variants. |
| See also | CIViC, HGVS Nomenclature
|
- Motivation
We have already added data on genes, drugs and diseases. Variants are key in linking these concepts for precision medicine and foster discussion in the community. With this property in place we can model the negative diagnostic association between a variant and a disease. Together with the provenance and the evidence. This property will allow us to connect a specific variant with evidence pertaining to its clinical significance as a predictor for the negative diagnostic of a disease phenotype. Emitraka (talk) 01:25, 12 November 2016 (UTC)
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Notified participants of WikiProject Medicine
- Discussion
Support Andrew Su (talk) 01:28, 12 November 2016 (UTC)- Support This property allows incorporating in Wikidata an important annotation for genetic variation in genomic and precision medicine that is not currently possible. This addition has two great added values: the expressivity for the type of biomarker the variant is, which is key in decision-making, and to clearly track the supporting evidence for each type of biomarker to evaluate the clinical actionability of the genetic variant for diagnosis. Wikidata is a perfect platform to create community discussion on the clinical value of biomarkers, specially relevant for the biomedical and clinical research community. Nuria Queralt (talk)
- Support --Andrawaag (talk) 06:06, 12 November 2016 (UTC)
- Support Required for modeling of variant/mutation impact in any species. Sebotic (talk) 18:44, 14 November 2016 (UTC)
- Support. This looks like a useful property for use in representing diseases and their treatments. YULdigitalpreservation (talk) 14:18, 15 November 2016 (UTC)
- Support but see above comment on positive diagnostic predictor --I9606 (talk) 20:07, 18 November 2016 (UTC)
- Support Putmantime (talk) 21:58, 18 November 2016 (UTC)
- @Emitraka, Andrew Su, NuriaQueralt, Andrawaag, Sebotic: @YULdigitalpreservation, I9606, Putmantime:
Done ArthurPSmith (talk) 15:39, 21 November 2016 (UTC)
