Wikidata:Property proposal/Positive modulator (biochemistry)
antisense inhibitor of
[edit]Originally proposed at Wikidata:Property proposal/Natural science
Description | protein/gene for which this chemical (e.g. a miRNA/siRNA) acts as an antisense inhibitor |
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Data type | Item |
Domain | biology, chemistry |
Allowed values | Wikidata items of instance of (P31)/subclass of (P279): chemical compound (Q11173) or protein (Q8054) |
Example | eteplirsen (Q5402585) → Dystrophin (Q412285) |
Source | Guide to Pharmacology, ChEMBL, BindingDB, PDB |
Planned use | Several thousand chemical compound to protein relations should be imported |
- Motivation
We have been importing proteins, chemical compounds and the relations between those and have modeled the relation by using physically interacts with (P129) and qualifiers to indicate the type of relation (e.g. Activator, Inhibitor). This approach is not very convenient. It makes adding data by users more difficult, as well as querying the data with SPARQL and it also makes it impossible to properly map these relations to external resources/ontologies. Therefore, we talked to the folks from ChEMBL and they kindly provided us with their list of chemical compound - protein mechanistic relations. We are currently also getting these relations established in the Relation Ontology which allows for interoperability and direct integration of these relations Wikidata with the OBO world. This is a big advantage, as data contributions to Wikidata can easily disseminate into the OBO world, making community curation in WD even more valuable. In total, there are 29 relations, I will now just propose the 10 most important as properties. Sebotic (talk) 19:05, 6 February 2017 (UTC)
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- Discussion
- Support ArthurPSmith (talk) 19:07, 16 February 2017 (UTC)
- Support -Emitraka (talk) 20:01, 16 February 2017 (UTC)
- Support NuriaQueralt (talk) 05:04, 26 February 2017 (UTC)
- Support Gstupp (talk) 18:45, 16 March 2017 (UTC)