Efficient Parameter Estimation Enables the Prediction of Drug Response Using a Mechanistic Pan-Cancer Pathway Model (Q90024379)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

title

Efficient Parameter Estimation Enables the Prediction of Drug Response Using a Mechanistic Pan-Cancer Pathway Model (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Jan Hasenauer

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

12

Hans Lehrach

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

11

Fabian J Theis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1

Fabian Fröhlich

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

author name string

Thomas Kessler

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Alexey Shadrin

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Leonard Schmiester

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Hendrik Hache

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Artur Muradyan

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Moritz Schütte

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Ji-Hyun Lim

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Matthias Heinig

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Christoph Wierling

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

Bodo Lange

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

publication date

28 November 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

page(s)

567-579.e6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

Oncogenic Signaling Pathways in The Cancer Genome Atlas.

10 April 2020

cites work

1 reference

31 March 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/J.CELL.2018.03.035

Metrics other than potency reveal systematic variation in responses to cancer drugs.

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Inferring catalysis in biological systems

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Lessons learned from quantitative dynamical modeling in systems biology

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Accelerated discovery via a whole-cell model

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Targeting cancer with small molecule kinase inhibitors

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

THE TOXICITY OF POISONS APPLIED JOINTLY

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Atlas of Cancer Signalling Network: a systems biology resource for integrative analysis of cancer data with Google Maps

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

On the relationship between sloppiness and identifiability

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Analyzing and interpreting genome data at the network level with ConsensusPathDB

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Systems biology and combination therapy in the quest for clinical efficacy.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Drug Resistance Resulting from Kinase Dimerization Is Rationalized by Thermodynamic Factors Describing Allosteric Inhibitor Effects

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

How to deal with parameters for whole-cell modelling.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Optimization and profile calculation of ODE models using second order adjoint sensitivity analysis.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Reactome: a database of reactions, pathways and biological processes

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Reverse engineering and identification in systems biology: strategies, perspectives and challenges

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Analysis of CFSE time-series data using division-, age- and label-structured population models

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Systematic identification of genomic markers of drug sensitivity in cancer cells

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

High-dimensional Bayesian parameter estimation: case study for a model of JAK2/STAT5 signaling.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

KEGG for representation and analysis of molecular networks involving diseases and drugs

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Integrating heterogeneous drug sensitivity data from cancer pharmacogenomic studies.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Identifying Important Risk Factors for Survival in Kidney Graft Failure Patients Using Random Survival Forests

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Predicting ligand-dependent tumors from multi-dimensional signaling features.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Reproducible pharmacogenomic profiling of cancer cell line panels.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Universally sloppy parameter sensitivities in systems biology models

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

BioPreDyn-bench: a suite of benchmark problems for dynamic modelling in systems biology

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Bayesian parameter estimation for biochemical reaction networks using region-based adaptive parallel tempering.

1 April 2022

2 references

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

1 April 2022

https://opencitations.net/index/coci/api/v1/citations/10.1093/BIOINFORMATICS/BTY229

Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

A whole-cell computational model predicts phenotype from genotype

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Comprehensive analysis of kinase inhibitor selectivity

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Parallelization and High-Performance Computing Enables Automated Statistical Inference of Multi-scale Models

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Comprehensive molecular portraits of human breast tumours

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Chemical combination effects predict connectivity in biological systems

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

DrugBank: a comprehensive resource for in silico drug discovery and exploration

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

A parallel metaheuristic for large mixed-integer dynamic optimization problems, with applications in computational biology

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Alternative drug sensitivity metrics improve preclinical cancer pharmacogenomics.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Inconsistency in large pharmacogenomic studies

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

iVUN: interactive Visualization of Uncertain biochemical reaction Networks

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Structural identifiability of systems biology models: a critical comparison of methods

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type-Specific Dynamic Logic Models.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

The concept of synthetic lethality in the context of anticancer therapy

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Scalable Parameter Estimation for Genome-Scale Biochemical Reaction Networks

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

MAPK signal pathways in the regulation of cell proliferation in mammalian cells

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Physicochemical modelling of cell signalling pathways.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Resources, standards and tools for systems biology

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Recon 2.2: from reconstruction to model of human metabolism

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

The target landscape of clinical kinase drugs.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

A community effort to assess and improve drug sensitivity prediction algorithms.

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

Data-driven reverse engineering of signaling pathways using ensembles of dynamic models

1 April 2022

1 reference

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELS.2018.10.013

10.1016/J.CELS.2018.10.013

1 April 2022

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30503647%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1 reference