Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome (Q27851703)

Kevin R Coombes

12

0 references

Garth Powis

24

Garth Powis

0 references

Ignacio I Wistuba

22

Vassiliki Papadimitrakopoulou

Ignacio I Wistuba

0 references

17

Vassiliki Papadimitrakopoulou

0 references

John V Heymach

23

John V Heymach

0 references

Roy S. Herbst

21

Roy S Herbst

0 references

George R Blumenschein

6

George R Blumenschein

0 references

Scott Lippman

19

Scott M Lippman

0 references

author name string

Nathan T Ihle

1

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Lauren A Byers

2

0 references

Edward S Kim

3

0 references

Pierre Saintigny

4

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J Jack Lee

5

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Anne Tsao

7

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Suyu Liu

8

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Jing Wang

10

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Lixia Diao

11

0 references

Lu Chen

13

0 references

Shuxing Zhang

14

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Mena F Abdelmelek

15

0 references

Ximing Tang

16

0 references

John D Minna

18

0 references

Waun K Hong

Journal of the National Cancer Institute

20

0 references

language of work or name

English

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publication date

8 February 2012

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published in

1 reference

Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling

PubMed

volume

104

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page(s)

228-39

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issue

3

0 references

cites work

1 reference

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

20 March 2017

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Structural basis for the interaction of Ras with RalGDS

20 March 2017

1 reference

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Scalable molecular dynamics with NAMD

20 March 2017

1 reference

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A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies

20 March 2017

1 reference

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The KRAS oncogene: past, present, and future

20 March 2017

1 reference

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Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

20 March 2017

1 reference

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

20 March 2017

1 reference

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7 April 2017

1 reference

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Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: etiopathogenic similarities, differences and paradoxes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274509

Are RAS mutations predictive markers of resistance to standard chemotherapy?

29 September 2017

1 reference

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Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms.

29 September 2017

1 reference

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KRAS mutations predict response to EGFR inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274509

Effects of mutant human Ki-ras(G12C) gene dosage on murine lung tumorigenesis and signaling to its downstream effectors

29 September 2017

1 reference

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Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274509

EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity

29 September 2017

1 reference

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Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274509

Differences in KRAS mutation spectrum in lung cancer cases between African Americans and Caucasians after occupational or environmental exposure to known carcinogens

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274509

Distinct requirements for Ras oncogenesis in human versus mouse cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274509

Prognostic value of specific KRAS mutations in lung adenocarcinomas.

29 September 2017

1 reference

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Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors

29 September 2017

1 reference

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Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study.

29 September 2017

1 reference

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Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.

2 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR523

Wordom: a program for efficient analysis of molecular dynamics simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR523

ZRANK: reranking protein docking predictions with an optimized energy function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR523

Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR523

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR523

21 January 2018

SnapShot: Ras Signaling

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR523

K-ras modulates the cell cycle via both positive and negative regulatory pathways

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22247021

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/JNCI/DJR523

1 reference

1822717

1822717

1 reference

1 reference

1 reference