Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients (Q38809615)

6 September 2017

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients (English)

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6 September 2017

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11

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6 September 2017

Sean P Kennedy

4

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Nora Rauch

Nora Rauch

6

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Melinda Halasz

Melinda Halasz

2

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Dirk Fey

Dirk Fey

1

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Boris Kholodenko

Boris N Kholodenko

12

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author name string

Daniel Dreidax

3

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6 September 2017

Jordan F Hastings

5

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6 September 2017

Amaya Garcia Munoz

7

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6 September 2017

Ruth Pilkington

8

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6 September 2017

Matthias Fischer

9

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6 September 2017

Frank Westermann

10

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6 September 2017

David R Croucher

13

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6 September 2017

22 December 2015

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6 September 2017

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8

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6 September 2017

ra130

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6 September 2017

408

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Signal transduction by the JNK group of MAP kinases

6 September 2017

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Phosphorylation networks regulating JNK activity in diverse genetic backgrounds

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Increased level of apoptosis in rat brains and SH-SY5Y cells exposed to excessive fluoride--a mechanism connected with activating JNK phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Fenretinide induces sustained-activation of JNK/p38 MAPK and apoptosis in a reactive oxygen species-dependent manner in neuroblastoma cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

The combined therapeutic effects of bortezomib and fenretinide on neuroblastoma cells involve endoplasmic reticulum stress response

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Oral RKS262 reduces tumor burden in a neuroblastoma xenograft animal model and mediates cytotoxicity through SAPK/JNK and ROS activation in vitro.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Signal integration by JNK and p38 MAPK pathways in cancer development

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

The JNK cascade as a biochemical switch in mammalian cells: ultrasensitive and all-or-none responses

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Bistability in the JNK cascade

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Crosstalk and signaling switches in mitogen-activated protein kinase cascades

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Progress in treatment and risk stratification of neuroblastoma: impact on future clinical and basic research

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

The MYCN enigma: significance of MYCN expression in neuroblastoma

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Molecular biology of neuroblastoma

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

The role of scaffold proteins in JNK signalling

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Mechanisms of MAPK signalling specificity

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Signaling through receptors and scaffolds: independent interactions reduce combinatorial complexity

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

The complexity of complexes in signal transduction.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

BioNetGen: software for rule-based modeling of signal transduction based on the interactions of molecular domains

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Exact model reduction of combinatorial reaction networks

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Specification, annotation, visualization and simulation of a large rule-based model for ERBB receptor signaling.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Data-based identifiability analysis of non-linear dynamical models

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Dynamical modeling and multi-experiment fitting with PottersWheel

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Global quantification of mammalian gene expression control

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Categorizing a prognostic variable: review of methods, code for easy implementation and applications to decision-making about cancer treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Towards a turning point of neuroblastoma therapy

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Comprehensive molecular portraits of human breast tumours

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Computational approaches for analyzing information flow in biological networks

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Signalling ballet in space and time

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

DNASU plasmid and PSI:Biology-Materials repositories: resources to accelerate biological research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

GSK3 inhibitors regulate MYCN mRNA levels and reduce neuroblastoma cell viability through multiple mechanisms, including p53 and Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Comparison of performance of one-color and two-color gene-expression analyses in predicting clinical endpoints of neuroblastoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Rules for modeling signal-transduction systems

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Guidelines for visualizing and annotating rule-based models

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Cell fate decisions are specified by the dynamic ERK interactome

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB0990

10.1126/SCISIGNAL.AAB0990

21 January 2018

Identifiers

DOI

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6 September 2017

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