Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies (Q79370601)

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22 December 2019

title

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies (English)

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22 December 2019

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Hyungjin Kim

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22 December 2019

Mubina Rafiuddin-Shah

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22 December 2019

Ho-Chou Tu

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John R Jeffers

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Gerard P Zambetti

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James J-D Hsieh

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Emily H-Y Cheng

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22 December 2019

publication date

19 November 2006

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22 December 2019

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22 December 2019

volume

8

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22 December 2019

page(s)

1348-1358

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22 December 2019

issue

12

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https://scigraph.springernature.com/pub.10.1038/ncb1499

22 December 2019

exact match

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cites work

Worms, life, and death (Nobel lecture).

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7 January 2021

Cell death: critical control points

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7 January 2021

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7 January 2021

Mitochondria and apoptosis

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7 January 2021

The Bcl2 family: regulators of the cellular life-or-death switch

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7 January 2021

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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7 January 2021

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

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7 January 2021

VDAC2 inhibits BAK activation and mitochondrial apoptosis

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7 January 2021

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

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7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

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7 January 2021

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

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7 January 2021

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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7 January 2021

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

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7 January 2021

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

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7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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7 January 2021

DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

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7 January 2021

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

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7 January 2021

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

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7 January 2021

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

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7 January 2021

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

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7 January 2021

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

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7 January 2021

Direct addition of BimL to mitochondria does not lead to cytochrome c release

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7 January 2021

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

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7 January 2021

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

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7 January 2021

p53 has a direct apoptogenic role at the mitochondria

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7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

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7 January 2021

Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors

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7 January 2021

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

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7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

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7 January 2021

Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death

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7 January 2021

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

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7 January 2021

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

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7 January 2021

WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak.

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7 January 2021

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

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7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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7 January 2021

Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death.

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7 January 2021

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

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7 January 2021

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

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7 January 2021

Integral role of Noxa in p53-mediated apoptotic response

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7 January 2021

Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death

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7 January 2021

Bad-deficient mice develop diffuse large B cell lymphoma

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7 January 2021

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

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7 January 2021

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

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7 January 2021

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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7 January 2021

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

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7 January 2021

Identifiers

DOI

10.1038/NCB1499

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17115033%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

22 December 2019

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