p53 has a direct apoptogenic role at the mitochondria (Q24298888)

Transformation related protein 53

GOA release 2020-03-11

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GOA release 2020-03-11

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5

Thomas Chittenden

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author name string

Motohiro Mihara

1

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Susan Erster

2

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Alexander Zaika

3

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Oleksi Petrenko

4

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Petr Pancoska

6

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Ute M Moll

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

7

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language of work or name

English

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publication date

March 2003

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published in

Molecular Cell

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volume

11

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page(s)

577-90

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issue

3

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cites work

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7 January 2021

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

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7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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7 January 2021

A polymorphic microsatellite that mediates induction of PIG3 by p53.

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7 January 2021

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

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7 January 2021

Essential role for caspase-8 in transcription-independent apoptosis triggered by p53

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7 January 2021

Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

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7 January 2021

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

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7 January 2021

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

1 reference

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7 January 2021

Activation of caspases in p53-induced transactivation-independent apoptosis.

1 reference

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7 January 2021

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

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7 January 2021

A matter of life and death

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Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

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7 January 2021

BH3-Only proteins-essential initiators of apoptotic cell death

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7 January 2021

New approaches to understanding p53 gene tumor mutation spectra

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7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

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7 January 2021

Bax directly induces release of cytochrome c from isolated mitochondria

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7 January 2021

A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function

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7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

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Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

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7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

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7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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7 January 2021

Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells

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7 January 2021

Mechanisms of p53-dependent apoptosis

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7 January 2021

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

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7 January 2021

Movement of Bax from the cytosol to mitochondria during apoptosis

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7 January 2021

Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis

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Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation

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7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

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7 January 2021

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

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7 January 2021

10.1016/S1097-2765(03)00050-9

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

1249077

1249077

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference