The Bcl2 family: regulators of the cellular life-or-death switch (Q29614982)

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12 November 2019

title

The Bcl2 family: regulators of the cellular life-or-death switch (English)

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30 April 2017

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12 November 2019

1

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12 November 2019

Jerry Adams

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2

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12 November 2019

author name string

Cory S

series ordinal

1

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30 April 2017

Adams JM

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2

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publication date

1 September 2002

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12 November 2019

language of work or name

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30 April 2017

published in

Nature Reviews Cancer

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12 November 2019

volume

2

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12 November 2019

issue

9

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12 November 2019

page(s)

647-656

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publication type of scholarly work

12 November 2019

review article

1 reference

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

cites work

1 reference

31 March 2020

The Hallmarks of Cancer

1 reference

A matter of life and death

31 March 2020

1 reference

Apoptosis: a link between cancer genetics and chemotherapy

31 March 2020

1 reference

Apoptosis in cancer therapy: crossing the threshold

31 March 2020

1 reference

The Bcl-2 protein family: arbiters of cell survival

31 March 2020

1 reference

Mitochondria and apoptosis

31 March 2020

1 reference

BCL-2 family members and the mitochondria in apoptosis

31 March 2020

1 reference

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

31 March 2020

1 reference

31 March 2020

1 reference

Life-or-death decisions by the Bcl-2 protein family.

31 March 2020

1 reference

Breaking the mitochondrial barrier

31 March 2020

1 reference

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

31 March 2020

1 reference

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

31 March 2020

1 reference

Mechanisms of caspase activation and inhibition during apoptosis

31 March 2020

1 reference

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

31 March 2020

1 reference

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

31 March 2020

1 reference

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

31 March 2020

1 reference

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

31 March 2020

1 reference

Solution structure of the antiapoptotic protein bcl-2

31 March 2020

1 reference

Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus

31 March 2020

1 reference

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

31 March 2020

1 reference

Structure of Bax: coregulation of dimer formation and intracellular localization

31 March 2020

1 reference

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

31 March 2020

1 reference

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

31 March 2020

1 reference

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

31 March 2020

1 reference

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

31 March 2020

1 reference

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

31 March 2020

1 reference

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

31 March 2020

1 reference

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

31 March 2020

1 reference

Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

31 March 2020

1 reference

Testicular degeneration in Bclw-deficient mice

31 March 2020

1 reference

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

31 March 2020

1 reference

BH3-Only proteins-essential initiators of apoptotic cell death

31 March 2020

1 reference

The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9

31 March 2020

1 reference

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

31 March 2020

1 reference

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

31 March 2020

1 reference

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

31 March 2020

1 reference

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

31 March 2020

1 reference

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

31 March 2020

1 reference

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

31 March 2020

1 reference

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

31 March 2020

1 reference

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

31 March 2020

1 reference

PUMA induces the rapid apoptosis of colorectal cancer cells

31 March 2020

1 reference

PUMA, a novel proapoptotic gene, is induced by p53

31 March 2020

1 reference

Molecular Cloning of a Novel Polypeptide, DP5, Induced during Programmed Neuronal Death

31 March 2020

1 reference

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

31 March 2020

1 reference

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

31 March 2020

1 reference

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

31 March 2020

1 reference

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

31 March 2020

1 reference

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

31 March 2020

1 reference

BID: a novel BH3 domain-only death agonist

31 March 2020

1 reference

Solution structure of BID, an intracellular amplifier of apoptotic signaling

31 March 2020

1 reference

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

31 March 2020

1 reference

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

31 March 2020

1 reference

Cardiolipin provides specificity for targeting of tBid to mitochondria

31 March 2020

1 reference

Rapid Kinetics of tBid-induced Cytochrome c and Smac/DIABLO Release and Mitochondrial Depolarization

31 March 2020

1 reference

tBID Homooligomerizes in the mitochondrial membrane to induce apoptosis

31 March 2020

1 reference

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

31 March 2020

1 reference

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

1 reference

Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations

31 March 2020

1 reference

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

31 March 2020

1 reference

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

31 March 2020

1 reference

Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane

31 March 2020

1 reference

Conformation of the Bax C-terminus regulates subcellular location and cell death

31 March 2020

1 reference

Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

31 March 2020

1 reference

VDAC regulation by the Bcl-2 family of proteins

31 March 2020

1 reference

The mitochondrion in apoptosis: how Pandora's box opens

31 March 2020

1 reference

Inhibition of Bax channel-forming activity by Bcl-2

31 March 2020

1 reference

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

31 March 2020

1 reference

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

31 March 2020

1 reference

A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast

31 March 2020

1 reference

Bim: a novel member of the Bcl-2 family that promotes apoptosis

31 March 2020

1 reference

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death

31 March 2020

1 reference

Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors.

31 March 2020

1 reference

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

31 March 2020

1 reference

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

31 March 2020

1 reference

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

31 March 2020

1 reference

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

31 March 2020

1 reference

WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

31 March 2020

1 reference

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

31 March 2020

1 reference

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

31 March 2020

1 reference

Caspases: their intracellular localization and translocation during apoptosis

31 March 2020

1 reference

The role of cytochrome c in caspase activation in Drosophila melanogaster cells

31 March 2020

1 reference

The role of ARK in stress-induced apoptosis in Drosophila cells

31 March 2020

1 reference

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

31 March 2020

1 reference

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

31 March 2020

1 reference

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

31 March 2020

1 reference

Differential requirement for caspase 9 in apoptotic pathways in vivo.

31 March 2020

1 reference

Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.

31 March 2020

1 reference

Adult Apaf-1-deficient mice exhibit male infertility

31 March 2020

1 reference

The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes

31 March 2020

1 reference

Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2.

31 March 2020

1 reference

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

31 March 2020

1 reference

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

31 March 2020

1 reference

Caspase-dependent cytosolic release of cytochrome c and membrane translocation of Bax in p53-induced apoptosis

31 March 2020

1 reference

Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling

31 March 2020

1 reference

Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases

31 March 2020

1 reference

p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.

31 March 2020

1 reference

The 'harmless' release of cytochrome c.

31 March 2020

1 reference

Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts

31 March 2020

1 reference

Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

31 March 2020

1 reference

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

31 March 2020

1 reference

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

31 March 2020

1 reference

31 March 2020

1 reference

The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.

31 March 2020

1 reference

Apoptosomes: engines for caspase activation

31 March 2020

1 reference

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

31 March 2020

1 reference

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

31 March 2020

1 reference

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

31 March 2020

1 reference

Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice

31 March 2020

1 reference

The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors

31 March 2020

1 reference

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

31 March 2020

1 reference

BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia

31 March 2020

1 reference

Selective regulation ofBcl-XLby a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies

31 March 2020

1 reference

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype

31 March 2020

1 reference

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

31 March 2020

1 reference

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

31 March 2020

1 reference

Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

31 March 2020

1 reference

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

31 March 2020

1 reference

The INK4a/ARF network in tumour suppression

31 March 2020

1 reference

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

31 March 2020

1 reference

Genetic analysis of chemoresistance in primary murine lymphomas.

31 March 2020

1 reference

Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines

31 March 2020

1 reference

Role of BAX in the apoptotic response to anticancer agents

31 March 2020

1 reference

From bench to clinic with apoptosis-based therapeutic agents

31 March 2020

1 reference

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

31 March 2020

1 reference

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

31 March 2020

1 reference

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

31 March 2020

1 reference

Bcl-2 family proteins as targets for anticancer drug design

31 March 2020

1 reference

Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs

31 March 2020

1 reference

Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

31 March 2020

1 reference

31 March 2020

Caspases: Enemies Within

1 reference

Caspase-9 and APAF-1 form an active holoenzyme

31 March 2020

1 reference

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation

31 March 2020

1 reference

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

31 March 2020

1 reference

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

31 March 2020

1 reference

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

31 March 2020

1 reference

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

31 March 2020

1 reference

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31 March 2020

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Dimensions publication ID

12 November 2019

1008451806

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30 April 2017

Consolidated OpenCitations Corpus – April 2017