CUL4B activates Wnt/β-catenin signalling in hepatocellular carcinoma by repressing Wnt antagonists. (Q55069974)

16 June 2018

title

CUL4B activates Wnt/β-catenin signalling in hepatocellular carcinoma by repressing Wnt antagonists. (English)

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16 June 2018

main subject

hepatocellular carcinoma

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9

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author name string

Jupeng Yuan

1

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16 June 2018

Bo Han

2

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16 June 2018

Huili Hu

3

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16 June 2018

Yanyan Qian

4

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16 June 2018

Zhaojian Liu

5

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16 June 2018

Zhao Wei

6

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16 June 2018

Xiaohong Liang

7

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16 June 2018

Baichun Jiang

8

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Yaoqin Gong

10

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publication date

23 January 2015

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published in

Journal of Pathology

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volume

235

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issue

5

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16 June 2018

page(s)

784-795

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Hepatocellular carcinoma: A global view.

cites work

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21 January 2018

Global cancer statistics

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21 January 2018

Hepatocellular carcinoma

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Hallmarks of Cancer: The Next Generation

21 January 2018

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Modelling the molecular circuitry of cancer

21 January 2018

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Wnt/beta-catenin signaling: components, mechanisms, and diseases

21 January 2018

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The Wnt signaling pathway in development and disease

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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

21 January 2018

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WNT signalling pathways as therapeutic targets in cancer

21 January 2018

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Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers.

21 January 2018

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beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance.

21 January 2018

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Wnt signaling in liver cancer

21 January 2018

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EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis.

21 January 2018

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Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway by influencing β-catenin in hepatocellular carcinoma

21 January 2018

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Upregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasion

21 January 2018

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Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection

21 January 2018

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Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

21 January 2018

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Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

21 January 2018

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Function and regulation of cullin-RING ubiquitin ligases

21 January 2018

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Cullin-RING ubiquitin ligases: global regulation and activation cycles

21 January 2018

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The cullin protein family

21 January 2018

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Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.

21 January 2018

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Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation

21 January 2018

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Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor

21 January 2018

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CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis

21 January 2018

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Cullin 4B is a novel prognostic marker that correlates with colon cancer progression and pathogenesis

21 January 2018

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CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing

21 January 2018

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Elevated expression of Wnt antagonists is a common event in hepatoblastomas

21 January 2018

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beta-catenin destruction complex: insights and questions from a structural perspective

21 January 2018

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Roles of Axin in the Wnt signalling pathway

21 January 2018

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Secreted antagonists of the Wnt signalling pathway

21 January 2018

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CRL4s: the CUL4-RING E3 ubiquitin ligases

21 January 2018

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Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation

21 January 2018

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Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase

21 January 2018

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X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression

21 January 2018

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Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands

21 January 2018

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Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis

21 January 2018

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MicroRNAs modulate the Wnt signaling pathway through targeting its inhibitors

21 January 2018

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Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma

21 January 2018

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Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.4492

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16 June 2018

PubMed ID

25430888

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16 June 2018