Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway by influencing β-catenin in hepatocellular carcinoma (Q39411411)

11 September 2017

title

Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway by influencing β-catenin in hepatocellular carcinoma (English)

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11 September 2017

S Fatima

1

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11 September 2017

N P Lee

2

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11 September 2017

F H Tsang

3

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11 September 2017

F T Kolligs

4

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11 September 2017

I O L Ng

5

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11 September 2017

R T P Poon

6

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11 September 2017

S T Fan

7

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11 September 2017

J M Luk

8

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11 September 2017

language of work or name

English

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publication date

16 January 2012

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11 September 2017

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11 September 2017

volume

31

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11 September 2017

issue

38

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11 September 2017

page(s)

4233-4244

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Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

11 September 2017

cites work

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Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells

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Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

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Promoter methylation and mRNA expression of DKK-3 and WIF-1 in hepatocellular carcinoma

21 January 2018

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Dickkopfs and Wnt/β-catenin signalling in liver cancer

21 January 2018

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DICKKOPF-4 activates the noncanonical c-Jun-NH2 kinase signaling pathway while inhibiting the Wnt-canonical pathway in human renal cell carcinoma

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Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways

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Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma

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Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection

21 January 2018

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The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors

21 January 2018

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RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis

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Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention.

21 January 2018

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Functional and structural diversity of the human Dickkopf gene family

21 January 2018

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Proteomic expression signature distinguishes cancerous and nonmalignant tissues in hepatocellular carcinoma

21 January 2018

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Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma

21 January 2018

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Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma

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MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties.

21 January 2018

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Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma

21 January 2018

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The Wnt signaling pathway in development and disease

21 January 2018

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Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin.

21 January 2018

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Wnt/beta-catenin signaling: components, mechanisms, and diseases

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.580

Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.580

Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.580

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

21 January 2018

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21 January 2018

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DICKKOPF-4 and -2 genes are upregulated in human colorectal cancer.

21 January 2018

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

21 January 2018

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The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology

21 January 2018

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Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.580

Function and biological roles of the Dickkopf family of Wnt modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Phosphorylation and regulation of beta-catenin by casein kinase I epsilon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

SFRP1 suppressed hepatoma cells growth through Wnt canonical signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Wnt antagonist family genes as biomarkers for diagnosis, staging, and prognosis of renal cell carcinoma using tumor and serum DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

CCN5, a secreted protein, localizes to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

p15RS Attenuates Wnt/β-Catenin Signaling by Disrupting β-Catenin·TCF4 Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Methylation of Dickkopf-3 as a prognostic factor in cirrhosis-related hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

The immunoglobulin-like cell adhesion molecule hepaCAM is cleaved in the human breast carcinoma MCF7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Absence of APC gene mutation in the mutation cluster region in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Dkk3, downregulated in cervical cancer, functions as a negative regulator of beta-catenin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

Allelic imbalance regions on chromosomes 8p, 17p and 19p related to metastasis of hepatocellular carcinoma: comparison between matched primary and metastatic lesions in 22 patients by genome-wide microsatellite analysis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.580

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7 January 2021

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Identifiers

DOI

10.1038/ONC.2011.580

1 reference

Dimensions Publication ID

11 September 2017

1025237395

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1 reference