Function and regulation of cullin-RING ubiquitin ligases (Q28131707)

Cul3-RING ubiquitin ligase complex

GO:0031464

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cullin-RING ubiquitin ligase complex

GO:0031463

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cytoplasmic SCF ubiquitin ligase complex

GO:0031461

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Cul4B-RING E3 ubiquitin ligase complex

GO:0043223

1 reference

Cul7-RING ubiquitin ligase complex

GO:0031465

1 reference

Cul5-RING ubiquitin ligase complex

GO:0031467

1 reference

SCF ubiquitin ligase complex

GO:0031466

1 reference

Cul2-RING ubiquitin ligase complex

GO:0019005

1 reference

nuclear SCF ubiquitin ligase complex

GO:0031462

1 reference

Nature Reviews Molecular Cell Biology

Matthew D Petroski

1

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Raymond J Deshaies

series ordinal

2

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publication date

January 2005

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language of work or name

English

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published in

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volume

6

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issue

1

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page(s)

9-20

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publication type of scholarly work

review article

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A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

Europe PubMed Central

cites work

1 reference

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

21 April 2017

1 reference

Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.

21 April 2017

1 reference

Identification of a Cullin Homology Region in a Subunit of the Anaphase-Promoting Complex

21 April 2017

1 reference

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

21 April 2017

1 reference

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

21 April 2017

1 reference

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 April 2017

1 reference

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

21 April 2017

1 reference

CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex

21 April 2017

1 reference

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

21 April 2017

1 reference

Cullin 4A associates with the UV-damaged DNA-binding protein DDB

21 April 2017

1 reference

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase

21 April 2017

1 reference

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

21 April 2017

1 reference

Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro

21 April 2017

1 reference

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

21 April 2017

1 reference

DNA Damage Response-mediated Degradation of Ho Endonuclease via the Ubiquitin System Involves Its Nuclear Export

21 April 2017

1 reference

Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast

21 April 2017

1 reference

Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly

21 April 2017

1 reference

The unstable F-box protein p58-Ctf13 forms the structural core of the CBF3 kinetochore complex

21 April 2017

1 reference

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

21 April 2017

1 reference

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

21 April 2017

1 reference

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

21 April 2017

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Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

21 April 2017

1 reference

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

21 April 2017

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Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

21 April 2017

1 reference

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

21 April 2017

1 reference

Degrading Ci: who is Cul-pable?

21 April 2017

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Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100

21 April 2017

1 reference

The SCF ubiquitin ligase: insights into a molecular machine

21 April 2017

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E3 ubiquitin ligase that recognizes sugar chains

21 April 2017

1 reference

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

21 April 2017

1 reference

Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk

21 April 2017

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Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase

21 April 2017

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Regulation of the transcription factor Gcn4 by Pho85 cyclin PCL5.

21 April 2017

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Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

21 April 2017

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Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation

21 April 2017

1 reference

Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins

21 April 2017

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SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4

21 April 2017

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The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

21 April 2017

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Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4.

21 April 2017

1 reference

Covalent modification of all members of human cullin family proteins by NEDD8

21 April 2017

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Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

21 April 2017

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An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

21 April 2017

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The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice

21 April 2017

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A novel protein modification pathway related to the ubiquitin system

21 April 2017

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Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome

21 April 2017

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Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

21 April 2017

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Structure of the Jab1/MPN Domain and Its Implications for Proteasome Function

21 April 2017

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NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases

21 April 2017

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CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

21 April 2017

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TIP120A associates with cullins and modulates ubiquitin ligase activity

21 April 2017

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Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation

21 April 2017

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Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U

21 April 2017

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SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex

21 April 2017

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Targeted proteomic study of the cyclin-Cdk module.

21 April 2017

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Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4.

21 April 2017

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Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

21 April 2017

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The ubiquitin ligase COP1 is a critical negative regulator of p53

21 April 2017

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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

21 April 2017

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

21 April 2017

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

21 April 2017

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Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

21 April 2017

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The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

21 April 2017

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A protein knockdown strategy to study the function of beta-catenin in tumorigenesis

21 April 2017

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Systematic analysis and nomenclature of mammalian F-box proteins

21 April 2017

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SCF and Cullin/Ring H2-based ubiquitin ligases

21 April 2017

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Parc: a cytoplasmic anchor for p53.

21 April 2017

1 reference

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

31 March 2020

1 reference

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

31 March 2020

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BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases

31 March 2020

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The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.

31 March 2020

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BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

31 March 2020

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Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases

31 March 2020

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Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components

31 March 2020

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

31 March 2020

1 reference

Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1

31 March 2020

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Regulating the Yeast Kinetochore by Ubiquitin-Dependent Degradation and Skp1p-Mediated Phosphorylation

31 March 2020

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Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.

31 March 2020

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Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination

31 March 2020

1 reference

Overproduction of polypeptides corresponding to the amino terminus of the F-box proteins Cdc4p and Met30p inhibits ubiquitin ligase activities of their SCF complexes

31 March 2020

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A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

31 March 2020

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Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases

31 March 2020

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Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

31 March 2020

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Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products

31 March 2020

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Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.

31 March 2020

1 reference

Stability of homologue of Slimb F-box protein is regulated by availability of its substrate

31 March 2020

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Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4.

31 March 2020

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Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain.

31 March 2020

1 reference

Dual regulation of the met4 transcription factor by ubiquitin-dependent degradation and inhibition of promoter recruitment

31 March 2020

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The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

31 March 2020

1 reference

Skp2 regulates Myc protein stability and activity

31 March 2020

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Regulation of transcriptional activation domain function by ubiquitin

31 March 2020

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When protein destruction runs amok, malignancy is on the loose

31 March 2020

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Oncogenic aberrations of cullin-dependent ubiquitin ligases

31 March 2020

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Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover

31 March 2020

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Phosphorylation of Sic1p by G 1 Cdk Required for Its Degradation and Entry into S Phase

31 March 2020

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Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation

31 March 2020

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Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation

31 March 2020

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Cyclin E-CDK2 is a regulator of p27Kip1.

31 March 2020

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

31 March 2020

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

31 March 2020

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Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex

31 March 2020

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Triggering ubiquitination of a CDK inhibitor at origins of DNA replication.

31 March 2020

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

31 March 2020

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Mathematical modeling suggests cooperative interactions between a disordered polyvalent ligand and a single receptor site

31 March 2020

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Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase

31 March 2020

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Intragenic suppression among CDC34 (UBC3) mutations defines a class of ubiquitin-conjugating catalytic domains

31 March 2020

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Cdc34 self-association is facilitated by ubiquitin thiolester formation and is required for its catalytic activity

31 March 2020

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An Essential Domain within Cdc34p Is Required for Binding to a Complex Containing Cdc4p and Cdc53p in Saccharomyces cerevisiae

31 March 2020

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Creation of a pluripotent ubiquitin-conjugating enzyme

31 March 2020

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Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.

31 March 2020

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Context of multiubiquitin chain attachment influences the rate of Sic1 degradation

31 March 2020

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Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast

31 March 2020

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A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination

31 March 2020

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Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization

31 March 2020

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NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

31 March 2020

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Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans.

31 March 2020

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Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.

31 March 2020

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Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex

31 March 2020

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JAMM: a metalloprotease-like zinc site in the proteasome and signalosome

31 March 2020

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COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases

31 March 2020

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Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p

31 March 2020

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Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms

31 March 2020

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Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCFTIR1 in Mediating Auxin Response

31 March 2020

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The COP9 Signalosome Promotes Degradation of Cyclin E during Early Drosophila Oogenesis

31 March 2020

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TIP120A associates with unneddylated cullin 1 and regulates its neddylation

31 March 2020

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Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1.

31 March 2020

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Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase

31 March 2020

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AtCAND1, a HEAT-repeat protein that participates in auxin signaling in Arabidopsis

31 March 2020

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HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis

31 March 2020

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Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein.

31 March 2020

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Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis during Drosophila oogenesis

31 March 2020

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An SCF-like ubiquitin ligase complex that controls presynaptic differentiation

31 March 2020

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SCFhFBH1 can act as helicase and E3 ubiquitin ligase

31 March 2020

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Exploring the functional complexity of cellular proteins by protein knockout

31 March 2020

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