The influence of the thymic environment on the CD4-versus-CD8 T lineage decision. (Q53653317)

16 May 2018

title

The influence of the thymic environment on the CD4-versus-CD8 T lineage decision. (English)

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16 May 2018

author name string

Matilde Canelles

1

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16 May 2018

Melissa L Park

2

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16 May 2018

Owen M Schwartz

3

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16 May 2018

B J Fowlkes

4

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16 May 2018

language of work or name

English

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publication date

13 July 2003

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16 May 2018

published in

Nature Immunology

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16 May 2018

volume

4

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16 May 2018

issue

8

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16 May 2018

page(s)

756-764

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16 May 2018

Selective events in T cell development

cites work

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Positive selection of T cells

21 January 2018

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Positive selection of thymocytes

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Signal strength in thymic selection and lineage commitment.

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The CD4/CD8 lineage decision: integration of signalling pathways

21 January 2018

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Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

21 January 2018

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The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

21 January 2018

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MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.

21 January 2018

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Lck activity controls CD4/CD8 T cell lineage commitment.

21 January 2018

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The influence of the MAPK pathway on T cell lineage commitment

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Requirement for sustained MAPK signaling in both CD4 and CD8 lineage commitment: a threshold model

21 January 2018

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Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus.

21 January 2018

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CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity

21 January 2018

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

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Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

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Evidence for differential intracellular signaling via CD4 and CD8 molecules

21 January 2018

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Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selection

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Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

21 January 2018

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The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.

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New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

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Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy.

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TCR signaling regulates thymic organization: lessons from TCR-transgenic mice

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Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment

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Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

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The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice

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Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells

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CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

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Fine tuning of TCR signaling by CD5.

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Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

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Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.

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T-cell development and the CD4-CD8 lineage decision

21 January 2018

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Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor

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T cell positive selection by a high density, low affinity ligand

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Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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Role of different T cell receptors in the development of pre-T cells.

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Bone marrow cells give rise to distinct cell clones within the thymus

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Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

21 January 2018

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7 January 2021

Thymic stromal organization is regulated by the specificity of T cell receptor/major histocompatibility complex interactions

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7 January 2021

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

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7 January 2021

Competition for specific intrathymic ligands limits positive selection in a TCR transgenic model of CD4+ T cell development

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7 January 2021

Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire

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7 January 2021

Cytotoxic monoclonal antibody specific for the Lyt-1.2 antigen

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7 January 2021

Premature TCR alpha beta expression and signaling in early thymocytes impair thymocyte expansion and partially block their development

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7 January 2021

Identifiers

DOI

10.1038/NI953

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16 May 2018

PubMed ID

12858172

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16 May 2018