T-cell development and the CD4-CD8 lineage decision (Q34659128)

3 August 2017

title

T-cell development and the CD4-CD8 lineage decision (English)

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3 August 2017

1

Ronald N Germain

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3 August 2017

publication date

1 May 2002

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Nature Reviews Immunology

3 August 2017

published in

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3 August 2017

volume

2

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3 August 2017

issue

5

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3 August 2017

page(s)

309-322

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publication type of scholarly work

3 August 2017

review article

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Feedback control of intercellular signalling in development

cites work

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In favor of the selective model of positive selection

21 January 2018

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CD3 Ligation on Immature Thymocytes Generates Antagonist-like Signals Appropriate for CD8 Lineage Commitment, Independently of T Cell Receptor Specificity

21 January 2018

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The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

21 January 2018

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The quantity of TCR signal determines positive selection and lineage commitment of T cells

21 January 2018

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Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus.

21 January 2018

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Structure and function of the pre-T cell receptor

21 January 2018

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Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex

21 January 2018

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Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

21 January 2018

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The thymus selects the useful, neglects the useless and destroys the harmful

21 January 2018

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How Many Thymocytes Audition for Selection?

21 January 2018

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The MHC reactivity of the T cell repertoire prior to positive and negative selection.

21 January 2018

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Signal transduction by the TCR for antigen

21 January 2018

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Transcriptional regulation of T lymphocyte development and function

21 January 2018

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The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

21 January 2018

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The T cell receptor for antigen: signaling and ligand discrimination

21 January 2018

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The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands

21 January 2018

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Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction

21 January 2018

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Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene

21 January 2018

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The regulation of CD4 and CD8 coreceptor gene expression during T cell development

21 January 2018

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Positive selection induces CD4 promoter and enhancer function

21 January 2018

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The notch pathway intermediate HES-1 silences CD4 gene expression

21 January 2018

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Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment

21 January 2018

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A molecular chart of thymocyte positive selection

21 January 2018

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Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

21 January 2018

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TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type.

21 January 2018

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Disruption of the CD4–major histocompatibility complex class II interaction blocks the development of CD4+T cellsin vivo

21 January 2018

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Requirement for sustained MAPK signaling in both CD4 and CD8 lineage commitment: a threshold model

21 January 2018

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Visualization of CD4/CD8 T cell commitment

21 January 2018

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Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness

21 January 2018

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The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.

21 January 2018

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Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase

21 January 2018

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Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development

21 January 2018

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21 January 2018

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Notch ligand-bearing thymic epithelial cells initiate and sustain Notch signaling in thymocytes independently of T cell receptor signaling

21 January 2018

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Distinct mechanisms contribute to generate and change the CD4:CD8 cell ratio during thymus development: a role for the Notch ligand, Jagged1.

21 January 2018

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Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development

21 January 2018

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Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

21 January 2018

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Stepwise specification of lymphocyte developmental lineages.

21 January 2018

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Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

21 January 2018

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Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

21 January 2018

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Early thymocyte development is regulated by modulation of E2A protein activity

21 January 2018

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Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

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Clonal Characterization of a Bipotent T Cell and NK Cell Progenitor in the Mouse Fetal Thymus

21 January 2018

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Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection

21 January 2018

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MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation

21 January 2018

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Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens

31 March 2020

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T Cell Subsets and the Recognition of MHC Class

31 March 2020

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The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation

31 March 2020

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Selective events in T cell development

31 March 2020

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Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function

31 March 2020

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Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

31 March 2020

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Preferential differentiation of T cell receptor specificities based on the MHC glycoproteins encountered during development. Evidence for positive selection

31 March 2020

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Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

31 March 2020

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Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

31 March 2020

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Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

31 March 2020

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Another view of the selective model of thymocyte selection

31 March 2020

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Development of mature CD8+ thymocytes: selection rather than instruction?

31 March 2020

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Lymphocyte lineage commitment: instruction versus selection

31 March 2020

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CD4/CD8 lineage commitment: back to instruction?

31 March 2020

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The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

31 March 2020

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MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent

31 March 2020

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The Influence of the MAPK Pathway on T Cell Lineage Commitment

31 March 2020

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Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus

31 March 2020

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CD8 lineage commitment in the absence of CD8.

31 March 2020

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Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

31 March 2020

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Molecular requirements for lineage commitment in the thymus--antibody-mediated receptor engagements reveal a central role for lck in lineage decisions

31 March 2020

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Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

31 March 2020

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Lck activity controls CD4/CD8 T cell lineage commitment.

31 March 2020

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Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

31 March 2020

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Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment

31 March 2020

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

31 March 2020

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Notch1 expression in early lymphopoiesis influences B versus T lineage determination

31 March 2020

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A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein

31 March 2020

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RAG-1-deficient mice have no mature B and T lymphocytes

31 March 2020

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Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

31 March 2020

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The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit

31 March 2020

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

31 March 2020

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alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

31 March 2020

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T-cell antigen receptor genes and T-cell recognition

31 March 2020

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Signal transduction by lymphocyte antigen receptors

31 March 2020

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

31 March 2020

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CD4 Augments the Response of a T Cell to Agonist but Not to Antagonist Ligands

31 March 2020

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A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

31 March 2020

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An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells

31 March 2020

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A Region in the CD8 Gene Locus That Directs Expression to the Mature CD8 T Cell Subset in Transgenic Mice

31 March 2020

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Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.

31 March 2020

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Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

31 March 2020

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Thymocyte lineage commitment: is it instructed or stochastic?

31 March 2020

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Stochastic component to development of class I major histocompatibility complex-specific T cells

31 March 2020

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Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice

31 March 2020

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T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages

31 March 2020

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Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages

31 March 2020

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Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection

31 March 2020

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Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes

31 March 2020

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Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.

31 March 2020

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Differentiation of CD4highCD8low coreceptor‐skewed thymocytes into mature CD8 single‐positive cells independent of MHC class I recognition

31 March 2020

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Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

31 March 2020

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A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection

31 March 2020

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Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways

31 March 2020

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Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

31 March 2020

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Evidence for a selective and multi-step model of T cell differentiation: CD4+CD8low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules

31 March 2020

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Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

31 March 2020

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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

31 March 2020

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CD4/CD8 lineage commitment: matching fate with competence

31 March 2020

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Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

31 March 2020

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Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling

31 March 2020

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Notch and the immune system.

31 March 2020

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An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

31 March 2020

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Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes

31 March 2020

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Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength

31 March 2020

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Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire

31 March 2020

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Does T-cell tolerance require a dedicated antigen-presenting cell?

31 March 2020

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A molecular map of T cell development.

31 March 2020

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Selective requirement for MAP kinase activation in thymocyte differentiation

31 March 2020

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Positive and negative selection invoke distinct signaling pathways.

31 March 2020

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Raf regulates positive selection

31 March 2020

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Degree of ERK activation influences both positive and negative thymocyte selection

31 March 2020

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MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

31 March 2020

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Activation events during thymic selection

31 March 2020

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Phenotypic changes accompanying positive selection of CD4+CD8+ thymocytes

31 March 2020

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Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1.

31 March 2020

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Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points

31 March 2020

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Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development.

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI798

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3 August 2017

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