Signal strength in thymic selection and lineage commitment. (Q34167971)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11228417%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

title

Signal strength in thymic selection and lineage commitment (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11228417%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11228417%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

author name string

Hogquist KA

series ordinal

1

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31 July 2017

publication date

1 April 2001

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11228417%20AND%20SRC:MED&resulttype=core&format=json

Current Opinion in Immunology

5 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11228417%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

volume

13

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11228417%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

issue

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11228417%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

page(s)

225-231

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11228417%20AND%20SRC:MED&resulttype=core&format=json

publication type of scholarly work

5 November 2019

review article

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T-cell-receptor affinity and thymocyte positive selection

cites work

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A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex

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Selection of the T cell repertoire.

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Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

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Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

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The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations

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Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire

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Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling

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7 January 2021

Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection

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Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes

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Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire

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Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

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7 January 2021

Tec family kinases modulate thresholds for thymocyte development and selection

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CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection

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7 January 2021

A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity

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CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

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7 January 2021

Positive Selection Through a Motif in the αβ T Cell Receptor

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7 January 2021

Positive and negative selection invoke distinct signaling pathways.

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7 January 2021

Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.

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7 January 2021

The Influence of the MAPK Pathway on T Cell Lineage Commitment

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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7 January 2021

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

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7 January 2021

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

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7 January 2021

Cytokines, virokines and the evolution of immunity

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7 January 2021

Receptor editing in developing T cells

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7 January 2021

Thymocyte selection: not by TCR alone

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7 January 2021

Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter

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7 January 2021

Signals involved in CD4/CD8 lineage commitment: current concepts and potential mechanisms

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7 January 2021

Stochastic component to development of class I major histocompatibility complex-specific T cells

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7 January 2021

Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment

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7 January 2021

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent

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7 January 2021

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

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7 January 2021

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

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7 January 2021

Interactions between the amino‐terminal domain of p56lck and cytoplasmic domains of CD4 and CD8α in yeast

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7 January 2021

Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo.

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7 January 2021

Lck activity controls CD4/CD8 T cell lineage commitment.

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7 January 2021

Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

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7 January 2021

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

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7 January 2021

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

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7 January 2021

Enhanced positive selection of a transgenic TCR by a restriction element that does not permit negative selection.

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7 January 2021

Degree of ERK activation influences both positive and negative thymocyte selection

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7 January 2021

Selective requirement for MAP kinase activation in thymocyte differentiation

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7 January 2021

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

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7 January 2021

An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

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7 January 2021

Correlating notch signaling with thymocyte maturation

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7 January 2021

MHC recognition in thymic development: distinct, parallel pathways for survival and lineage commitment.

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7 January 2021

Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes

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7 January 2021

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

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7 January 2021

Regulation of lineage commitment distinct from positive selection

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7 January 2021

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity

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7 January 2021

The Shaping of the T Cell Repertoire

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7 January 2021

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

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7 January 2021

10.1016/S0952-7915(00)00208-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11228417%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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