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Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation. (Q40922234)

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scientific article published on November 1996

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English	Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.	scientific article published on November 1996

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934573%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934573%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

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1

1 reference

Europe PubMed Central

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21 October 2019

author name string

R N Germain

2

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Europe PubMed Central

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21 October 2019

publication date

1 November 1996

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21 October 2019

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934573%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934573%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

5

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Europe PubMed Central

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21 October 2019

461-477

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934573%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice

1 reference

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7 January 2021

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Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

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Another view of the selective model of thymocyte selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

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A challenge to the instructive model of positive selection

1 reference

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7 January 2021

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Mice lacking MHC class II molecules

1 reference

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7 January 2021

based on heuristic

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Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages

1 reference

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7 January 2021

based on heuristic

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Thymocyte lineage commitment: is it instructed or stochastic?

1 reference

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7 January 2021

based on heuristic

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Disrupted development of thymocytes expressing a transgenic TCR upon CD4 overexpression

1 reference

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7 January 2021

based on heuristic

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Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

1 reference

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7 January 2021

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T-cell antigen receptor genes and T-cell recognition

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

T cell receptor antagonist peptides induce positive selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Stochastic component to development of class I major histocompatibility complex-specific T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Specificity and flexibility in thymic selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Upregulation of surface markers on dying thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Small cortical thymocytes are subject to positive selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Generation of mature T cell populations in the thymus: CD4 or CD8 down-regulation occurs at different stages of thymocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro differentiation and commitment of CD4+ CD8+ thymocytes to the CD4 lineage, without TCR engagement

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for differential intracellular signaling via CD4 and CD8 molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective events in T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Thymic emigration: conveyor belts or lucky dips?

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Development of mature CD8+ thymocytes: selection rather than instruction?

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The different roles of MHC class recognition in thymocyte CD4 versus CD8 lineage commitment and positive selection.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo and in vitro clonal deletion of double-positive thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The selection of the α,β heterodimeric T-cell receptor for antigen

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The T-cell receptor for antigen in T-cell development and repertoire selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The thymus selects the useful, neglects the useless and destroys the harmful

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of thymocyte negative selection by T cell receptor antagonist peptides

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Positive selection of CD4-CD8+ T cells in the thymus of normal mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

CD8 is required during positive selection of CD4-/CD8+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980502-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1074-7613(00)80502-6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934573%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

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https://api.fatcat.wiki/v0/release/gednumhn5zfltaczjrcr3bplma

24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934573%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

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