E1A binding protein p300 (Q5323823)

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mammalian protein found in Homo sapiens
  • p300 HAT
  • histone crotonyltransferase p300
  • E1A-binding protein, 300kD
  • EP300
  • histone acetyltransferase p300
  • E1A-associated protein p300
  • histone butyryltransferase p300
  • protein 2-hydroxyisobutyryltransferase p300
  • protein propionyltransferase p300
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Language Label Description Also known as
English
E1A binding protein p300
mammalian protein found in Homo sapiens
  • p300 HAT
  • histone crotonyltransferase p300
  • E1A-binding protein, 300kD
  • EP300
  • histone acetyltransferase p300
  • E1A-associated protein p300
  • histone butyryltransferase p300
  • protein 2-hydroxyisobutyryltransferase p300
  • protein propionyltransferase p300

Statements

part of
molecular function
transcription factor binding
determination method
IEA
IPI
5 references
retrieved
1 January 2018
stated in
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IEA
protein binding
determination method
IPI
107 references
retrieved
1 January 2018
stated in
A novel cofactor for p300 that regulates the p53 response
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Dendrite development regulated by CREST, a calcium-regulated transcriptional activator
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes.
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Induction of SOX4 by DNA damage is critical for p53 stabilization and function
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Binding and modulation of p53 by p300/CBP coactivators
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Kruppel-like factor 15 is critical for vascular inflammation
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Acetylation of Sirt2 by p300 attenuates its deacetylase activity
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
BRD7 is a candidate tumour suppressor gene required for p53 function
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Lyl1 interacts with CREB1 and alters expression of CREB1 target genes
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
The Smad3 linker region contains a transcriptional activation domain
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
A novel Rb- and p300-binding protein inhibits transactivation by MyoD
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
A novel cofactor for p300 that regulates the p53 response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Direct suppression of Stat1 function during adenoviral infection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Activation of rapid oestrogen signalling in aggressive human breast cancers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Bovine herpesvirus 1 immediate-early protein (bICP0) interacts with the histone acetyltransferase p300, which stimulates productive infection and gC promoter activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Acetyltransferase p300 regulates NBS1-mediated DNA damage response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Induction of SOX4 by DNA damage is critical for p53 stabilization and function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
cAMP response element-binding protein-binding protein binds to human papillomavirus E2 protein and activates E2-dependent transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Acetylation is indispensable for p53 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
An acetyl-methyl switch drives a conformational change in p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
An AUTS2-Polycomb complex activates gene expression in the CNS.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Cooperative activation of human papillomavirus type 8 gene expression by the E2 protein and the cellular coactivator p300.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Novel nucleolar pathway connecting intracellular energy status with p53 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Acetylation-dependent regulation of Skp2 function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
p53 Stabilization and accumulation induced by human vaccinia-related kinase 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Human ALKBH4 interacts with proteins associated with transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Structural features of human histone acetyltransferase p300 and its complex with p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
BRD7 is a candidate tumour suppressor gene required for p53 function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Synergistic activation of transcription by CBP and p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Specificity of cyclin E-Cdk2, TFIIB, and E1A interactions with a common domain of the p300 coactivator
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
The corepressor activity of Alien is controlled by CREB-binding protein/p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Bovine herpesvirus 1 immediate-early protein (bICP0) interacts with the histone acetyltransferase p300, which stimulates productive infection and gC promoter activity
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
retrieved
1 January 2018
stated in
Hepatitis C virus core protein regulates p300/CBP co-activation function. Possible role in the regulation of NF-AT1 transcriptional activity
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IPI
acetyltransferase activity
determination method
EXP
IDA
IEA
IMP
7 references
retrieved
1 January 2018
stated in
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IEA
retrieved
1 January 2018
stated in
CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IDA
retrieved
1 January 2018
stated in
Acetylation of Sirt2 by p300 attenuates its deacetylase activity
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IDA
retrieved
1 January 2018
stated in
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
EXP
retrieved
1 January 2018
stated in
NF-kappaB RelA phosphorylation regulates RelA acetylation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
EXP
retrieved
1 January 2018
stated in
BRD7 is a candidate tumour suppressor gene required for p53 function
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
EXP
transcription coactivator activity
determination method
IDA
IEA
7 references
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IEA
retrieved
1 January 2018
stated in
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IDA
retrieved
1 January 2018
stated in
Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IDA
retrieved
1 January 2018
stated in
P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IDA
retrieved
1 January 2018
stated in
The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IDA
retrieved
1 January 2018
stated in
Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IDA
histone acetyltransferase activity
determination method
IEA
IDA
TAS
8 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IEA
retrieved
1 January 2018
stated in
Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IDA
retrieved
1 January 2018
stated in
Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IDA
retrieved
1 January 2018
stated in
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IDA
retrieved
1 January 2018
stated in
Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer
GOA
curator
UniProt
UniProt protein ID
Q09472
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09472&geneProductId=UniProtKB:Q09472
determination method
IDA
cell component
biological process
Gene Atlas image
PBB GE EP300 202221 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D050881
subject named as
E1A-Associated p300 Protein
0 references
PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q5323823&oldid=2116714639"