The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP (Q24295229)

2

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Javier Girardini

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Paul Smith

4

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Milena Gasco

5

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Xin Lu

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Tim Crook

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Giannino Del Sal

Nature Structural & Molecular Biology

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publication date

October 2007

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language of work or name

English

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published in

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volume

14

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issue

10

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page(s)

912-20

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cites work

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The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

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A Role for the Polyproline Domain of p53 in Its Regulation by Mdm2

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The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53

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The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

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Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity

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A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

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iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.

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Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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Pin1 links the activities of c-Abl and p300 in regulating p73 function.

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Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).

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Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

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Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins

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Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes

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Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation

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DNA-dependent acetylation of p53 by the transcription coactivator p300.

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Pin1 modulates the structure and function of human RNA polymerase II.

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.

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ASPP proteins specifically stimulate the apoptotic function of p53

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Cyclin E ablation in the mouse

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MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

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