EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300 (Q24319939)

2

0 references

Zhichao Mei

3

0 references

Zhou Wang

4

0 references

Wuhan Xiao

Molecular and Cellular Biology

5

0 references

language of work or name

English

0 references

publication date

March 2014

0 references

published in

0 references

volume

34

0 references

issue

6

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page(s)

1085-99

0 references

cites work

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U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia

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Hypoxia-regulated target genes implicated in tumor metastasis

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Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function

27 September 2017

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Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia

27 September 2017

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Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

27 September 2017

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MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

27 September 2017

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27 September 2017

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Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis

27 September 2017

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Hypoxia and hypoxia-inducible factors: master regulators of metastasis

27 September 2017

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HIF-2alpha deletion promotes Kras-driven lung tumor development.

27 September 2017

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Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation

27 September 2017

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An essential role of the HIF-1alpha-c-Myc axis in malignant progression

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27 September 2017

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U19/Eaf2 binds to and stabilizes von hippel-lindau protein

27 September 2017

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27 September 2017

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27 September 2017

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Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation

27 September 2017

1 reference

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Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice

27 September 2017

1 reference

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Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development

27 September 2017

1 reference

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The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

27 September 2017

1 reference

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Hypoxia-inducible factors: central regulators of the tumor phenotype

27 September 2017

1 reference

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Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

27 September 2017

1 reference

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Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

Elongation factor ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

Genetic evidence for a tumor suppressor role of HIF-2alpha.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

Small molecule modulators of histone acetyltransferase p300.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958035

p53 inhibits hypoxia-inducible factor-stimulated transcription

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24421387