Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function (Q45345758)

13 December 2017

title

Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function (English)

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13 December 2017

Ian R Watson

1

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13 December 2017

Alvaro Blanch

2

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13 December 2017

Dan C C Lin

3

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13 December 2017

Michael Ohh

4

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13 December 2017

Meredith S Irwin

5

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13 December 2017

publication date

14 September 2006

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Journal of Biological Chemistry

13 December 2017

language of work or name

English

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published in

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13 December 2017

volume

281

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13 December 2017

issue

45

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13 December 2017

page(s)

34096-34103

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p73 is a simian [correction of human] p53-related protein that can induce apoptosis

13 December 2017

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Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

21 January 2018

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Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo

21 January 2018

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21 January 2018

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DeltaN-p73alpha accumulates in human neuroblastic tumors

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Aberrant expression of DeltaNp73 in benign and malignant tumours of the prostate: correlation with Gleason score

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TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma.

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

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21 January 2018

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Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

21 January 2018

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21 January 2018

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Characterization of NEDD8, a Developmentally Down-regulated Ubiquitin-like Protein

21 January 2018

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

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DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

21 January 2018

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RETRACTED: p73alpha regulation by Chk1 in response to DNA damage

21 January 2018

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PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73

21 January 2018

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A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity

21 January 2018

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The ubiquitin-protein ligase Itch regulates p73 stability

21 January 2018

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Mdm2 binds p73 alpha without targeting degradation

21 January 2018

1 reference

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MDM2 and MDMX bind and stabilize the p53-related protein p73

21 January 2018

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MDM2 suppresses p73 function without promoting p73 degradation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

21 January 2018

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21 January 2018

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21 January 2018

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A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

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21 January 2018

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

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Regulation of the p73 protein stability and degradation

21 January 2018

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Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

21 January 2018

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

21 January 2018

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

21 January 2018

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p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

21 January 2018

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p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis

21 January 2018

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Ubiquitin-dependent degradation of p73 is inhibited by PML.

21 January 2018

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MDM2 and MDMX can interact differently with ARF and members of the p53 family

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M603654200

1 reference

13 December 2017

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