Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity (Q24297369)

Gene Ontology release 2020-05-02

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1990444

Parkin RBR E3 ubiquitin protein ligase

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GOA release 2020-03-11

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John F Staropoli

1

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Caroline McDermott

2

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Cécile Martinat

3

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Brenda Schulman

4

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Elena Demireva

5

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Asa Abeliovich

Ubiquitin, cellular inclusions and their role in neurodegeneration

6

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language of work or name

English

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publication date

6 March 2003

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published in

Neuron

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volume

37

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page(s)

735-49

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issue

5

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cites work

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Programmed cell death: does it play a role in Parkinson's disease?

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

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Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation

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Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

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Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E

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ebi regulates epidermal growth factor receptor signaling pathways in Drosophila

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Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity

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Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases.

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Induction of midbrain dopaminergic neurons by Sonic hedgehog

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

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7 January 2021

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

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RING finger proteins: mediators of ubiquitin ligase activity

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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The harlequin mouse mutation downregulates apoptosis-inducing factor

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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

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RNAi functions in cultured mammalian neurons

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Parkin is associated with cellular vesicles

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Parkinson's disease. First of two parts

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The ubiquitin pathway in Parkinson's disease.

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Neuronal apoptosis at the G1/S cell cycle checkpoint

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Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons.

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Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

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Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo

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The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons

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Etiology and pathogenesis of Parkinson's disease

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Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis.

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Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents

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Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

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7 January 2021

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons

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Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

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The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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7 January 2021

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

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Alpha-synuclein in Lewy bodies

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

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7 January 2021

Protection against dopaminergic nigrostriatal cell death by excitatory input ablation

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Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation.

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7 January 2021

Kainic acid-induced apoptosis in cerebellar granule neurons: an attempt at cell cycle re-entry

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7 January 2021

Culprits in the degradation of cyclin E apprehended

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Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin

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7 January 2021

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

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7 January 2021

The HIV-1 DNA flap stimulates HIV vector-mediated cell transduction in the brain.

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7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900084-9

7 January 2021