Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. (Q48569616)

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19 January 2020

title

Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function (English)

1 reference

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Amyloid beta precursor protein

19 January 2020

main subject

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negative regulation of long-term synaptic potentiation

GOA release 2020-03-11

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Membrane metallo endopeptidase

GOA release 2020-03-11

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GOA release 2020-03-11

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4

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19 January 2020

7

Matthias Staufenbiel

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19 January 2020

author name string

Shu-Ming Huang

1

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19 January 2020

Akihiro Mouri

2

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19 January 2020

Hideko Kokubo

3

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19 January 2020

Takahiro Suemoto

5

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19 January 2020

Makoto Higuchi

6

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19 January 2020

Yukihiro Noda

8

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19 January 2020

Haruyasu Yamaguchi

9

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19 January 2020

Toshitaka Nabeshima

10

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19 January 2020

Takaomi C Saido

11

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19 January 2020

Nobuhisa Iwata

12

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19 January 2020

language of work or name

English

0 references

publication date

24 April 2006

1 reference

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Journal of Biological Chemistry

19 January 2020

published in

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19 January 2020

volume

281

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19 January 2020

page(s)

17941-17951

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19 January 2020

issue

26

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

19 January 2020

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Metabolism of amyloid-beta peptide and Alzheimer's disease

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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

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Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

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Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

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Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

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Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology

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Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

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Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.

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Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Alzheimer's disease is a synaptic failure

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

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Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

21 January 2018

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

21 January 2018

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Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

21 January 2018

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21 January 2018

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21 January 2018

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Identifiers

DOI

10.1074/JBC.M601372200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16636059%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference